正常志愿者对5-HT1A受体激动剂氟司必林的激素和体温反应。
Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers.
作者信息
Pitchot William, Wauthy Jacques, Hansenne Michel, Pinto Emmanuel, Fuchs Sonia, Reggers Jean, Legros Jean-Jacques, Ansseau Marc
机构信息
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium.
出版信息
Psychopharmacology (Berl). 2002 Oct;164(1):27-32. doi: 10.1007/s00213-002-1177-0. Epub 2002 Jul 30.
RATIONALE
Flesinoxan is a highly potent and selective 5-HT(1A) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe.
OBJECTIVES
We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers.
METHODS
In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min.
RESULTS
Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent.
CONCLUSIONS
These results showed the role of 5-HT(1A) mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
原理
氟西汀是一种高效且选择性的5-羟色胺（1A）激动剂，似乎是一种潜在有趣的神经内分泌5-羟色胺能探针。
目的
我们评估了正常志愿者对氟西汀的激素（促肾上腺皮质激素、皮质醇、催乳素和生长激素）及体温反应。
方法
在一项双盲安慰剂对照研究中，以1周的间隔向12名健康男性志愿者在10分钟内单次注射0.5毫克和1毫克剂量。在-30、0、15、30、60、90和120分钟时测量体温和激素反应。
结果
氟西汀导致促肾上腺皮质激素（ACTH）、皮质醇、催乳素（PRL）、生长激素（GH）显著且剂量依赖性增加，体温降低。对氟西汀的耐受性良好。
结论
这些结果显示了5-羟色胺（1A）机制在对氟西汀的PRL、ACTH、皮质醇、GH及体温反应中的作用。在本研究中，氟西汀似乎是一种非常有前景的5-羟色胺能神经内分泌探针。
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