阿片类药物及其拮抗剂行为效应的决定因素：心理生物学实验室的贡献。
Determinants of the behavioral effects of opioids and their antagonists: contributions of the Laboratory of Psychobiology.
作者信息
Woods J H, France C P
机构信息
Department of Pharmacology, 1301 MSRB III, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA.
出版信息
Psychopharmacology (Berl). 2002 Oct;163(3-4):406-11. doi: 10.1007/s00213-002-1212-1. Epub 2002 Aug 29.
RATIONALE
The behavioral pharmacology of opioids has been influenced significantly by the research and writings of Drs. Peter B. Dews, Roger T. Kelleher, and William H. Morse, their colleagues, and their students.
OBJECTIVE
Their conceptual and methodological approach to the topic is reviewed briefly, and three areas of research are described to provide an empirical perspective.
RESULTS
The objective of determining the general effects of opioids on behavior is described; the effects of opioids on schedule-controlled behavior and punished behavior are described and compared to non-opioids. The differential effects of opioid antagonists on responding reinforced by different stimuli are also presented.
CONCLUSION
The conceptual and methodological approach taken by the group, as well as their discoveries in the behavioral pharmacology of opioids, will continue to exert a positive influence on the field.
理论依据
彼得·B·杜斯博士、罗杰·T·凯莱赫博士和威廉·H·莫尔斯博士及其同事和学生的研究与著作对阿片类药物的行为药理学产生了重大影响。
目的
简要回顾他们对该主题的概念和方法，描述三个研究领域以提供实证视角。
结果
描述了确定阿片类药物对行为的一般影响的目标；描述了阿片类药物对按计划控制行为和受惩罚行为的影响，并与非阿片类药物进行了比较。还介绍了阿片类拮抗剂对不同刺激强化反应的差异影响。
结论
该团队采用的概念和方法，以及他们在阿片类药物行为药理学方面的发现，将继续对该领域产生积极影响。
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