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胱氨酸/谷氨酸交换是细胞外谷氨酸的来源：反复给予可卡因后的改变。

Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.

作者信息

Baker D A, Shen H, Kalivas P W

机构信息

Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston South Carolina 29425, USA.

出版信息

Amino Acids. 2002;23(1-3):161-2. doi: 10.1007/s00726-001-0122-6.

DOI:10.1007/s00726-001-0122-6
PMID:12373531
Abstract

Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.

摘要

通过微透析测量发现，反复给予可卡因会降低伏隔核中谷氨酸的基础细胞外水平。所呈现的研究表明，反复使用可卡因引发的这种长期神经适应性变化是由于胱氨酸/谷氨酸交换活性降低所致。

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