Changes in the basic nuclear proteins of the cellular slime mould Dictyostelium discoideum during growth and differentiation.

Nuclei isolated from myxamoebae and differentiating cells (slug stage) of Dictyostelium discoideum contain similar ratios of DNA, RNA and protein (1:8:29) and acid soluble proteins present in amounts equal in weight to the nuclear DNA can be extracted therefrom. On urea polyacrylamide gels these basic proteins were shown to be very similar with the exception of one band, present in the myxamoebae, which was virtually absent from the differentiating cells.