HPC2/ELAC2基因多态性与前列腺癌风险：按疾病发病年龄进行的分析
HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease.
作者信息
Meitz J C, Edwards S M, Easton D F, Murkin A, Ardern-Jones A, Jackson R A, Williams S, Dearnaley D P, Stratton M R, Houlston R S, Eeles R A
机构信息
Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
出版信息
Br J Cancer. 2002 Oct 7;87(8):905-8. doi: 10.1038/sj.bjc.6600564.
The candidate prostate cancer susceptibility gene HPC2/ELAC2 has two common coding polymorphisms: (Ser-->Leu 217) and (Ala-->Thr 541). The Thr541 variant in the HPC2/ELAC2 gene has previously been reported to be at an increased frequency in prostate cancer cases. To evaluate this hypothesis we genotyped 432 prostate cancer patients (including 262 patients diagnosed <or=55 years) and 469 UK, population based control individuals with no family history of cancer. We found no significant difference in the frequencies of Thr541-containing genotypes between cases and controls (OR=1.41, 95% CI 0.79-2.50). The association remained non-significant when the analysis was restricted to cases divided by age of onset into those diagnosed <or=55 years (OR=1.50, 95% CI 0.79-2.85) or to patients diagnosed >55 years (OR=1.27, 95% CI 0.59-2.74). We conclude that any association between the Thr541 variant and prostate cancer is likely to be weak.
候选前列腺癌易感基因HPC2/ELAC2有两种常见的编码多态性：（Ser→Leu 217）和（Ala→Thr 541）。先前有报道称，HPC2/ELAC2基因中的Thr541变体在前列腺癌病例中的出现频率有所增加。为了评估这一假设，我们对432名前列腺癌患者（包括262名诊断时年龄≤55岁的患者）和469名无癌症家族史的英国对照个体进行了基因分型。我们发现病例组和对照组中含Thr541基因型的频率没有显著差异（比值比=1.41，95%置信区间0.79 - 2.50）。当分析仅限于按发病年龄分为诊断时年龄≤55岁的病例（比值比=1.50，95%置信区间0.79 - 2.85）或诊断时年龄＞55岁的患者（比值比=1.27，95%置信区间0.59 - 2.74）时，这种关联仍然不显著。我们得出结论，Thr541变体与前列腺癌之间的任何关联可能都很微弱。
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