Vanharanta M, Mursu J, Nurmi T, Voutilainen S, Rissanen T H, Salonen R, Adlercreutz H, Salonen J T
The Research Institute of Public Health, University of Kuopio, Kuopio, Finland.
Eur J Clin Nutr. 2002 Oct;56(10):952-7. doi: 10.1038/sj.ejcn.1601510.
To analyse the lignan content of phloem powder enriched rye bread and to study the dose-response relationship of the effect of dietary plant lignans derived from phloem on intestinal production of enterolactone by measuring enterolactone concentration in serum.
A randomized double-blind supplementation trial.
Seventy-five non-smoking men recruited by newspaper advertisements.
Subjects were randomized to three study groups receiving either rye bread high in phloem (HP, 14% of rye flour substituted with phloem powder), rye bread low in phloem (LP, 7% of rye flour substituted with phloem powder) or placebo rye bread. Participants consumed 70 g of study bread daily for 4 weeks and provided serum samples for enterolactone analysis at baseline and at the end of the intervention.
There was a significant increase in serum enterolactone concentration in the LP and HP groups compared with the placebo group (P=0.009 and P=0.003, respectively). Considerable interindividual differences were observed in the response to dietary lignans within the study groups.
Our results indicate that plant lignans attached to insoluble fibre layer in phloem can be further metabolized and converted to enterolactone presumably by the bacteria present in the colon. Phloem powder is useful source of lignans for functional foods aimed to elevate serum enterolactone levels.
Phloem powder and the study breads were provided by Finnpettu Oy and Linkosuo Oy, respectively. The clinical study work was sponsored in part by Oy Jurilab Ltd.
分析富含韧皮部粉末的黑麦面包中的木脂素含量，并通过测量血清中肠内酯的浓度，研究源自韧皮部的膳食植物木脂素对肠道内肠内酯生成影响的剂量反应关系。
一项随机双盲补充试验。
通过报纸广告招募的75名不吸烟男性。
受试者被随机分为三个研究组，分别接受高韧皮部黑麦面包（HP，用韧皮部粉末替代14%的黑麦粉）、低韧皮部黑麦面包（LP，用韧皮部粉末替代7%的黑麦粉）或安慰剂黑麦面包。参与者每天食用70克研究面包，持续4周，并在基线和干预结束时提供血清样本用于肠内酯分析。
与安慰剂组相比，LP组和HP组的血清肠内酯浓度显著升高（分别为P = 0.009和P = 0.003）。在研究组内，观察到个体对膳食木脂素的反应存在相当大的差异。
我们的结果表明，附着在韧皮部不溶性纤维层上的植物木脂素可能会被结肠中的细菌进一步代谢并转化为肠内酯。韧皮部粉末是用于旨在提高血清肠内酯水平的功能性食品的有用木脂素来源。
韧皮部粉末和研究面包分别由Finnpettu Oy和Linkosuo Oy提供。临床研究工作部分由Oy Jurilab Ltd赞助。
