Pietinen P, Stumpf K, Männistö S, Kataja V, Uusitupa M, Adlercreutz H
Department of Nutrition, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.
Cancer Epidemiol Biomarkers Prev. 2001 Apr;10(4):339-44.
Phytoestrogens have been linked to a risk of breast cancer. The main phytoestrogens in the Finnish diet are lignans, and enterolactone is quantitatively the most important circulating lignan. The purpose of this study was to examine the association between serum enterolactone and risk of breast cancer in Finnish women. The subjects were participants of the Kuopio Breast Cancer Study: This analysis concerns 194 breast cancer cases (68 premenopausal and 126 postmenopausal) who entered the study before diagnosis and 208 community-based controls. They completed a validated food frequency questionnaire referring to the previous 12 months and gave serum samples before the examinations. The measurement of serum enterolactone was performed by time-resolved fluoroimmunoassay. The statistical analyses were done by the logistic regression method. The mean serum enterolactone concentration was 20 nmol/l for the cases and 26 nmol/l for the controls (P 0.003). The mean serum enterolactone concentration in the lowest quintile was 3.0 nmol/l and 54.0 nmol/l in the highest. The odds ratio in the highest quintile of enterolactone values adjusted for all of the known risk factors for breast cancer was 0.38 (95% confidence interval,0.18-0.77; P for trend, 0.03). The inverse association between serum enterolactone and risk of breast cancer was seen both among premenopausal and postmenopausal women. High enterolactone level was associated with higher consumption of rye products and tea and higher intake of dietary fiber and vitamin E compared with those with low serum enterolactone values. Serum enterolactone level was significantly inversely associated with risk of breast cancer.
植物雌激素与乳腺癌风险有关。芬兰饮食中的主要植物雌激素是木脂素，而肠内酯是循环木脂素中数量上最重要的一种。本研究的目的是探讨芬兰女性血清肠内酯与乳腺癌风险之间的关联。研究对象为库奥皮奥乳腺癌研究的参与者：本分析涉及194例在诊断前进入研究的乳腺癌病例（68例绝经前和126例绝经后）以及208名社区对照者。他们完成了一份经过验证的、涉及前12个月的食物频率问卷，并在检查前提供了血清样本。血清肠内酯的测定采用时间分辨荧光免疫分析法。统计分析采用逻辑回归方法。病例组血清肠内酯平均浓度为20 nmol/l，对照组为26 nmol/l（P = 0.003）。最低五分位数组的血清肠内酯平均浓度为3.0 nmol/l，最高五分位数组为54.0 nmol/l。在对所有已知乳腺癌风险因素进行调整后，肠内酯值最高五分位数组的比值比为0.38（95%置信区间，0.18 - 0.77；趋势检验P = 0.03）。绝经前和绝经后女性中均观察到血清肠内酯与乳腺癌风险之间存在负相关。与血清肠内酯值低的人相比，肠内酯水平高与黑麦产品和茶的摄入量较高以及膳食纤维和维生素E的摄入量较高有关。血清肠内酯水平与乳腺癌风险显著负相关。
