[使用高灵敏度雌二醇放射免疫分析试剂盒对神经性厌食症患者性腺功能的研究]

[Studies on the gonadal function in patients with anorexia nervosa using a highly sensitive radioimmunoassay kit for estradiol].

作者信息

Jibiki Kazuko, Hotta Mari, Okaji Rie, Odagiri Emi, Takano Kazue

机构信息

Central Clinical Laboratories, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666.

出版信息

Rinsho Byori. 2002 Aug;50(8):824-9.

PMID:12373821

Abstract

We measured serum estradiol (E2) using a highly sensitive radioimmunoassay kit in patients with anorexia nervosa (AN). It is possible to determine the ovarian function with hypogonadism in patients with AN whose levels of E2 were below 10 pg/ml. In patients with extremely low levels of BMI (less than 15 kg/m2), basal levels of E2, LH, FSH and IGF-I increased significantly with gain of body weight. Recovery of the hypothalamic-pituitary-ovarian function in AN patients were correlated with weight gain and nutritional status. The levels of IGF-I and E2 raised in advance of gonadotropins. Using highly sensitive assay of E2, we recognized the clinical usefulness for evaluation of the ovarian function in patients with AN in the course of treatment.

摘要

我们使用高灵敏度放射免疫分析试剂盒对神经性厌食症（AN）患者的血清雌二醇（E2）进行了测量。对于E2水平低于10 pg/ml的AN患者，有可能确定其性腺功能减退情况。在体重指数（BMI）极低（低于15 kg/m2）的患者中，随着体重增加，E2、促黄体生成素（LH）、促卵泡生成素（FSH）和胰岛素样生长因子-I（IGF-I）的基础水平显著升高。AN患者下丘脑-垂体-卵巢功能的恢复与体重增加和营养状况相关。IGF-I和E2的水平在促性腺激素之前升高。通过对E2的高灵敏度检测，我们认识到其在评估AN患者治疗过程中卵巢功能方面的临床实用性。