Nadel A, Waddell G, Volow M, Escueta A V
Epilepsia. 1975 Sep;16(3):511-20. doi: 10.1111/j.1528-1157.1975.tb06081.x.
A 25-year-old man presented with seizures characterized by unconsciousness, automatic behavior, and myoclonic jerks lasting 0.5 to 8 sec. Videotape analysis of 300 simultaneously recorded electroencephalographic and clinical attacks revealed 8- to 9-Hz 150 to 200 muV sharp waves beginning in both medial temporal areas during eyelid flutters. When discharges spread diffusely on both sides and lasted 2 to 3 sec, 20 degrees forward flexion of the head, unconsciousness, pupil dilation, and staring became evident. Asymmetrical myoclonic jerks invariably appeared. When paroxysms were greater than 3 sec, automatisms and tonic posturing occurred. The electroencephalographic and clinical seizures appeared during the awake and relaxed states, i.e., with normal alpha rhythm. They were suppressed during physical and mental activities and during sleep, i.e., in the absence of alpha rhythm. Our studies suggest that these seizures associated with diffuse electroencephalographic alpha-like activities are subcortical in origin and should be tested in their responsivity to alpha suppressants and inducers.
一名25岁男性出现癫痫发作，其特征为意识丧失、自动行为以及持续0.5至8秒的肌阵挛性抽搐。对300次同步记录的脑电图和临床发作进行录像分析发现，在眼睑颤动期间，双侧颞内侧区域开始出现8至9赫兹、150至200微伏的尖波。当放电双侧弥漫性扩散并持续2至3秒时，头部向前屈曲20度、意识丧失、瞳孔散大以及凝视变得明显。不对称性肌阵挛性抽搐总是会出现。当发作超过3秒时，会出现自动症和强直性姿势。脑电图和临床发作出现在清醒和放松状态，即具有正常的α节律时。它们在体力和脑力活动期间以及睡眠期间，即在没有α节律时受到抑制。我们的研究表明，这些与弥漫性脑电图α样活动相关的发作起源于皮层下，应该测试它们对α抑制剂和诱导剂的反应性。
