高剂量的可乐福辛多帕酯可增强犬膈肌收缩力。
High-dose colforsin daropate increases diaphragmatic contractility in dogs.
作者信息
Fujii Yoshitaka, Toyooka Hidenori
机构信息
Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.
出版信息
Can J Anaesth. 2002 Oct;49(8):877-9. doi: 10.1007/BF03017425.
PURPOSE
To evaluate the effects of colforsin daropate, a water-soluble derivate known to improve contractility in fatigued canine diaphragm, at two different doses (low-dose and high-dose) on contractility of the non-fatigued diaphragm of dogs.
METHODS
Twenty-four pentobarbitone-anesthetized dogs were divided into three groups of eight each: Group I received no study drug; Group II received low-dose (0.2 microg x kg-1 x min-1) colforsin daropate; Group III received high-dose (0.5 microg x kg-1 x min-1) colforsin daropate. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi).
RESULTS
In Group III, with an infusion of high-dose colforsin daropate, Pdi at low-frequency (20 Hz) and high-frequency (100 Hz) stimulation increased from baseline values (P < 0.05). Compared with Group I, Pdi at both stimuli increased during colforsin daropate administration in Group III (P < 0.05). In Group II, with an infusion of low- dose colforsin daropate, Pdi to each stimulus did not change.
CONCLUSION
Colforsin daropate, only when administered at high-dose, increases contractility of non-fatigued diaphragm in dogs.
目的
评估已知可改善疲劳犬膈肌收缩力的水溶性衍生物双丁酰环磷腺苷钙在两种不同剂量（低剂量和高剂量）下对犬非疲劳膈肌收缩力的影响。
方法
将24只戊巴比妥麻醉的犬分为三组，每组8只：第一组未接受研究药物；第二组接受低剂量（0.2微克·千克⁻¹·分钟⁻¹）双丁酰环磷腺苷钙；第三组接受高剂量（0.5微克·千克⁻¹·分钟⁻¹）双丁酰环磷腺苷钙。通过跨膈压（Pdi）评估膈肌收缩力。
结果
在第三组中，输注高剂量双丁酰环磷腺苷钙后，低频（20赫兹）和高频（100赫兹）刺激下的Pdi较基线值增加（P<0.05）。与第一组相比，第三组在输注双丁酰环磷腺苷钙期间两种刺激下的Pdi均增加（P<0.05）。在第二组中，输注低剂量双丁酰环磷腺苷钙后，每种刺激下的Pdi均未改变。
结论
双丁酰环磷腺苷钙仅在高剂量给药时可增加犬非疲劳膈肌的收缩力。
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