• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.硫黄素 S 阳性淀粉样沉积物在转基因小鼠和阿尔茨海默病中的神经毒性作用。
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13990-5. doi: 10.1073/pnas.222433299. Epub 2002 Oct 9.
2
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.Tg-SwDI转基因小鼠在β-淀粉样前体蛋白（AβPP）加工、Aβ降解和弹性淀粉样血管病方面表现出新型改变。
Am J Pathol. 2008 Aug;173(2):483-93. doi: 10.2353/ajpath.2008.071191. Epub 2008 Jul 3.
3
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.在同时过度表达阿尔茨海默病突变早老素1和淀粉样前体蛋白瑞典突变体的转基因小鼠中，与年龄相关的淀粉样β沉积与整体神经元丢失无关。
Am J Pathol. 2000 Jul;157(1):331-9. doi: 10.1016/s0002-9440(10)64544-0.
4
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.在老年斑中，CLAC与β淀粉样蛋白40或硫黄素S反应性大多呈分离分布，这揭示了β淀粉样蛋白沉积物的两个不同亚群。
Am J Pathol. 2004 Jul;165(1):273-81. doi: 10.1016/s0002-9440(10)63295-6.
5
Impact of CRFR1 Ablation on Amyloid-β Production and Accumulation in a Mouse Model of Alzheimer's Disease.促肾上腺皮质激素释放因子受体1基因敲除对阿尔茨海默病小鼠模型中β淀粉样蛋白生成及聚集的影响
J Alzheimers Dis. 2015;45(4):1175-84. doi: 10.3233/JAD-142844.
6
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.阿尔茨海默病转基因小鼠模型中对淀粉样变性的炎症反应。
Am J Pathol. 2001 Apr;158(4):1345-54. doi: 10.1016/S0002-9440(10)64085-0.
7
Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.使用基质辅助激光解吸电离成像质谱法描绘转基因阿尔茨海默病小鼠（tgArcSwe）中与淀粉样斑块相关的神经元鞘脂
ACS Chem Neurosci. 2017 Feb 15;8(2):347-355. doi: 10.1021/acschemneuro.6b00391. Epub 2017 Jan 10.
8
Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions.通过通路损伤，淀粉样前体蛋白/早老素1双转基因小鼠中的弥漫性淀粉样蛋白沉积减少，但斑块数量未减少。
Neuroscience. 2003;119(4):1185-97. doi: 10.1016/s0306-4522(03)00215-x.
9
Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease.阿尔茨海默病APPswe/PS1DeltaE9转基因小鼠模型视网膜中的β-淀粉样蛋白沉积与功能损害
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):793-800. doi: 10.1167/iovs.08-2384. Epub 2008 Sep 12.
10
Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.转 5XFAD、APP/PS1KI 和 3xTG 小鼠及散发性和家族性阿尔茨海默病中 Aβ₅-x 样免疫反应产物的丰度。
Mol Neurodegener. 2014 Apr 2;9:13. doi: 10.1186/1750-1326-9-13.

引用本文的文献

1
Stilbenes Against Alzheimer's Disease: A Comprehensive Review of Preclinical Studies of Natural and Synthetic Compounds Combined with the Contributions of Developed Nanodrug Delivery Systems.芪类化合物抗阿尔茨海默病：天然及合成化合物临床前研究综述以及新型纳米药物递送系统的贡献
Molecules. 2025 Apr 29;30(9):1982. doi: 10.3390/molecules30091982.
2
Interleukin-6 deficiency reduces neuroinflammation by inhibiting the STAT3-cGAS-STING pathway in Alzheimer's disease mice.白细胞介素-6 缺乏通过抑制阿尔茨海默病小鼠中的 STAT3-cGAS-STING 通路减少神经炎症。
J Neuroinflammation. 2024 Nov 1;21(1):282. doi: 10.1186/s12974-024-03277-3.
3
Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.类胡萝卜素补充剂缓解阿尔茨海默病症状。
Int J Mol Sci. 2024 Aug 18;25(16):8982. doi: 10.3390/ijms25168982.
4
Monoclonal Antibody Therapy in Alzheimer's Disease.阿尔茨海默病的单克隆抗体疗法
Pharmaceutics. 2023 Dec 29;16(1):60. doi: 10.3390/pharmaceutics16010060.
5
Nanotechnology for microglial targeting and inhibition of neuroinflammation underlying Alzheimer's pathology.用于针对小胶质细胞和抑制阿尔茨海默病病理学中神经炎症的纳米技术。
Transl Neurodegener. 2024 Jan 4;13(1):2. doi: 10.1186/s40035-023-00393-7.
6
Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer's Disease.糖尿病所固有的、与痴呆症（阿尔茨海默病）发展相关的生理机制。
Neurol Int. 2023 Oct 10;15(4):1253-1272. doi: 10.3390/neurolint15040079.
7
Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.阿尔茨海默病中 Aβ 斑块、神经原纤维缠结和 APOE 的不同转录组反应。
Alzheimers Dement. 2024 Jan;20(1):74-90. doi: 10.1002/alz.13387. Epub 2023 Jul 17.
8
Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and in Alzheimer's Disease.阿尔茨海默病中对β淀粉样蛋白斑块、神经原纤维缠结及[此处原文缺失内容]的不同转录组反应
bioRxiv. 2023 Mar 21:2023.03.20.533303. doi: 10.1101/2023.03.20.533303.
9
Post-mortem brain histological examination in the substantia nigra and subthalamic nucleus in Parkinson's disease following deep brain stimulation.帕金森病患者接受脑深部刺激后黑质和丘脑底核的尸检脑组 织学检查
Front Neurosci. 2022 Sep 14;16:948523. doi: 10.3389/fnins.2022.948523. eCollection 2022.
10
Excited-State Intramolecular Hydrogen Transfer of Compact Molecules Controls Amyloid Aggregation Profiles.紧密分子的激发态分子内氢转移控制淀粉样蛋白聚集特征。
JACS Au. 2022 Aug 11;2(9):2001-2012. doi: 10.1021/jacsau.2c00281. eCollection 2022 Sep 26.

本文引用的文献

1
Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.脑淀粉样血管病APP23转基因小鼠模型中的胆碱能变化
J Neurosci. 2002 Apr 15;22(8):3234-43. doi: 10.1523/JNEUROSCI.22-08-03234.2002.
2
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.由β淀粉样蛋白42原纤维诱导的P301l tau转基因小鼠中神经原纤维缠结的形成。
Science. 2001 Aug 24;293(5534):1491-5. doi: 10.1126/science.1062097.
3
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.在表达突变型tau蛋白和淀粉样前体蛋白（APP）的转基因小鼠中神经原纤维变性增强。
Science. 2001 Aug 24;293(5534):1487-91. doi: 10.1126/science.1058189.
4
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.阿尔茨海默病转基因模型中斑块诱导的神经突几何形状异常：对神经系统破坏的影响。
J Neuropathol Exp Neurol. 2001 Aug;60(8):753-8. doi: 10.1093/jnen/60.8.753.
5
Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.携带突变型APP（swe）和/或PS1（M146L）转基因小鼠的神经病理学：p75（NTR）胆碱能基底前脑隔海马通路的改变。
Exp Neurol. 2001 Aug;170(2):227-43. doi: 10.1006/exnr.2001.7710.
6
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.在阿尔茨海默病的转基因小鼠模型中，纤维状β-淀粉样蛋白引发氧化损伤。
Neuroscience. 2001;104(3):609-13. doi: 10.1016/s0306-4522(01)00115-4.
7
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.在同时过度表达阿尔茨海默病突变早老素1和淀粉样前体蛋白瑞典突变体的转基因小鼠中，与年龄相关的淀粉样β沉积与整体神经元丢失无关。
Am J Pathol. 2000 Jul;157(1):331-9. doi: 10.1016/s0002-9440(10)64544-0.
8
Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias.联合皮质中微柱状集合体的描述及其在阿尔茨海默病和路易体痴呆中的破坏。
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5039-43. doi: 10.1073/pnas.060009897.
9
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.β淀粉样蛋白与淀粉样前体蛋白相互作用：阿尔茨海默病中的一种潜在毒性机制。
Nat Neurosci. 2000 May;3(5):460-4. doi: 10.1038/74833.
10
The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors.不同早老素1和早老素2突变对家族性阿尔茨海默病大脑中淀粉样蛋白沉积、神经原纤维变化及神经元丢失的影响：其他表型修饰因子的证据
Brain. 1999 Sep;122 ( Pt 9):1709-19. doi: 10.1093/brain/122.9.1709.

硫黄素 S 阳性淀粉样沉积物在转基因小鼠和阿尔茨海默病中的神经毒性作用。

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.

作者信息

Urbanc B, Cruz L, Le R, Sanders J, Ashe K Hsiao, Duff K, Stanley H E, Irizarry M C, Hyman B T

机构信息

Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA.

出版信息

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13990-5. doi: 10.1073/pnas.222433299. Epub 2002 Oct 9.

DOI:10.1073/pnas.222433299
PMID:12374847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC137824/
Abstract

Despite extensive deposition of putatively neurotoxic amyloid-beta (Abeta) protein in the brain, it has not been possible to demonstrate an association of Abeta deposits with neuronal loss in Alzheimer's disease (AD), and neuronal loss is minimal in transgenic mouse models of AD. Using triple immunostaining confocal microscopy and analyzing the images with the cross-correlation density map method from statistical physics, we directly compared Abeta deposition, Abeta morphology, and neuronal architecture. We found dramatic, focal neuronal toxicity associated primarily with thioflavin S-positive fibrillar Abeta deposits in both AD and PSAPP mice. These results, along with computer simulations, suggest that Abeta develops neurotoxic properties in vivo when it adopts a fibrillar beta-pleated sheet conformation.

摘要

尽管在大脑中存在大量推测具有神经毒性的β淀粉样蛋白（Aβ）沉积，但在阿尔茨海默病（AD）中，尚未证实Aβ沉积与神经元丢失之间存在关联，并且在AD转基因小鼠模型中神经元丢失极少。我们使用三重免疫染色共聚焦显微镜，并采用统计物理学中的互相关密度图方法对图像进行分析，直接比较了Aβ沉积、Aβ形态和神经元结构。我们发现，在AD和PSAPP小鼠中，显著的局灶性神经元毒性主要与硫黄素S阳性的纤维状Aβ沉积有关。这些结果以及计算机模拟表明，当Aβ采用纤维状β折叠片构象时，它在体内会产生神经毒性特性。