体细胞克隆
Somatic cell nuclear transfer.
作者信息
Wilmut I, Beaujean N, de Sousa P A, Dinnyes A, King T J, Paterson L A, Wells D N, Young L E
机构信息
Roslin Institute, Roslin, Midlothian EH25 9PS, UK.
出版信息
Nature. 2002 Oct 10;419(6907):583-6. doi: 10.1038/nature01079.
PMID:12374931
Abstract
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
摘要
通过成年体细胞进行核移植的克隆是发育可塑性的一个显著例证。当一个细胞核被置于卵母细胞的细胞质中时，控制分化的染色质结构变化可以被逆转，并且细胞核能够被促使控制发育直至足月。
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