肾上腺外嗜铬细胞瘤的诊断定位：（123）I-间碘苄胍显像与（131）I-间碘苄胍显像的比较

Diagnostic localization of extra-adrenal pheochromocytoma: comparison of (123)I-MIBG imaging and (131)I-MIBG imaging.

作者信息

Nakatani Tatsuya, Hayama Takuma, Uchida Junji, Nakamura Kenji, Takemoto Yoshiaki, Sugimura Kazunobu

机构信息

Department of Urology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan.

出版信息

Oncol Rep. 2002 Nov-Dec;9(6):1225-7.

PMID:12375024

Abstract

The accurate diagnostic localization of extra-adrenal pheochromocytoma is important in the treatment of primary and metastatic tumors. In this study, we report on a case of extra-adrenal pheochromocytoma in which the tumor could not be diagnosed by 131I-metaiodobenzylguanidine (MIBG) scintigraphy but only by 123I-MIBG scintigraphy. Our patient was a 16-year old girl whose chief complaint was headaches. High levels of catecholamines were detected in the blood and urine samples. 131I-MIBG scintigraphy could not detect any abnormal accumulation, but an accumulation of 123I-MIBG was found in the pelvis. Magnetic resonance imaging (MRI) revealed a broad-based bladder tumor at the site of the accumulation. Partial cystectomy was performed, and immunohistochemical staining examination confirmed the diagnosis of extra-adrenal pheochromocytoma in the urinary bladder. In this report, we compare 131I-MIBG scintigraphy with 123I-MIBG scintigraphy and discuss their characteristics.

摘要

肾上腺外嗜铬细胞瘤的准确诊断定位对于原发性和转移性肿瘤的治疗至关重要。在本研究中，我们报告了一例肾上腺外嗜铬细胞瘤病例，该肿瘤无法通过131I-间碘苄胍（MIBG）闪烁扫描法诊断，而只能通过123I-MIBG闪烁扫描法诊断。我们的患者是一名16岁女孩，主要症状为头痛。在血液和尿液样本中检测到高水平的儿茶酚胺。131I-MIBG闪烁扫描法未检测到任何异常聚集，但在骨盆中发现了123I-MIBG的聚集。磁共振成像（MRI）显示在聚集部位有一个基底较宽的膀胱肿瘤。进行了部分膀胱切除术，免疫组织化学染色检查证实膀胱内肾上腺外嗜铬细胞瘤的诊断。在本报告中，我们比较了131I-MIBG闪烁扫描法与123I-MIBG闪烁扫描法并讨论了它们的特点。