Benn P A, Egan J F X, Ingardia C J
Department of Pediatrics, University of Connecticut Health Center, Farmington 06030-6140, USA.
J Matern Fetal Neonatal Med. 2002 Apr;11(4):262-5. doi: 10.1080/jmf.11.4.262.265.
To compare second-trimester maternal serum analyte values in Down syndrome pregnancies with, and without, hydrops fetalis.
Seven hydropic and 85 non-hydropic Down syndrome pregnancies were identified among women with positive second-trimester maternal serum screening results. Values for maternal serum alpha-fetoprotein (MSAFP), human chorionic gonadotropin (hCG), unconjugated estriol and inhibin-A, and risks for Down syndrome were compared using the non-parametric Mann-Whitney statistical test.
Hydropic Down syndrome pregnancies had significantly lower MSAFP and estriol concentrations, while hCG levels were higher. For subgroups of five hydropic and 42 non-hydropic cases, no statistically significant difference in the inhibin-A levels could be demonstrated.
Second-trimester Down syndrome screening risks are significantly higher in affected pregnancies that are complicated by fetal hydrops.
比较孕中期唐氏综合征妊娠合并与未合并胎儿水肿时孕妇血清分析物值。
在孕中期孕妇血清筛查结果为阳性的女性中，确定了7例水肿型和85例非水肿型唐氏综合征妊娠。使用非参数曼-惠特尼统计检验比较孕妇血清甲胎蛋白（MSAFP）、人绒毛膜促性腺激素（hCG）、非结合雌三醇和抑制素A的值以及唐氏综合征风险。
水肿型唐氏综合征妊娠的MSAFP和雌三醇浓度显著较低，而hCG水平较高。对于5例水肿型和42例非水肿型病例的亚组，抑制素A水平无统计学显著差异。
在合并胎儿水肿的受影响妊娠中，孕中期唐氏综合征筛查风险显著更高。
