Abliz Paride, Fukushima Kazutaka, Takizawa Kayoko, Yang Rongya, Li Ruoyu, Nishimura Kazuko
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, Japan.
Diagn Microbiol Infect Dis. 2002 Sep;44(1):17-22. doi: 10.1016/s0732-8893(02)00425-x.
Infection with Trichosporon asahii is a major cause of deep-seated and disseminated trichosporonosis, which is associated with a high mortality rate. Disseminated trichosporonosis in individuals with no underlying disease has not been reported. In this study, we report the identification of the first isolate of Trichosporon asahii var. asahii in China. Two isolates were obtained from the liver and skin of a patient with disseminated trichosporonosis who displayed no evidence of underlying disease. The morphologic and physiologic characteristics of the two isolates differed slightly from those of usual strains of T. asahii var. asahii, including the type strain CBS 2479. Ubiquinone-9 was identified as the major ubiquinone in both isolates. Sequence analysis of the LSUrDNA D1/D2, ITS, and IGS1 regions from the two isolates showed them to be T. asahii var. asahii, and random amplified polymorphic DNA analysis strongly suggested that they were the same strain.
阿萨希毛孢子菌感染是深部和播散性毛孢子菌病的主要病因，该病死亡率较高。尚未有关于无基础疾病个体发生播散性毛孢子菌病的报道。在本研究中，我们报告了中国首例阿萨希毛孢子菌阿萨希变种的分离鉴定。从一名患有播散性毛孢子菌病且无基础疾病证据的患者的肝脏和皮肤中获得了两株菌株。这两株菌株的形态和生理特征与阿萨希毛孢子菌阿萨希变种的常见菌株略有不同，包括模式菌株CBS 2479。在这两株菌株中均鉴定出泛醌-9为主要泛醌。对这两株菌株的LSUrDNA D1/D2、ITS和IGS1区域进行序列分析，结果显示它们为阿萨希毛孢子菌阿萨希变种，随机扩增多态性DNA分析强烈表明它们是同一菌株。
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