Park Jae Yong, Park Sun Hee, Choi Jin Eun, Lee Su Yeon, Jeon Hyo-Sung, Cha Sung Ick, Kim Chang Ho, Park Jae-Ho, Kam Sin, Park Rang Woon, Kim In-San, Jung Tae Hoon
Department of Internal Medicine, Kyungpook National University Hospital, Taegu 700-412, Korea.
Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):993-7.
Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may influence an individual's susceptibility to smoking-related cancer. We investigated the association between two polymorphisms of the DNA repair gene XPA and risk of lung cancer in the Korean population. Two XPA polymorphisms (A23G and G709A) were typed in 265 lung cancer patients and 185 healthy controls who were frequency-matched on age and sex. The XPA G709A polymorphism was not detected in cases and controls. The XPA 23 GG genotype was associated with a significantly decreased risk for lung cancer [odds ratio (OR), 0.56; 95% confidence interval (CI), 0.35-0.90] when the combined AA and AG genotype was used as the reference. The reduction in risk for the XPA 23 GG genotype was significant in males (OR, 0.51; 95% CI, 0.30-0.86), younger individuals (OR, 0.39; 95% CI, 0.19-0.80), and current smokers (OR, 0.46; 95% CI, 0.25-0.83). These results suggest that the XPA A23G polymorphism contributes to genetic susceptibility for lung cancer.
DNA修复基因中的多态性可能与DNA损伤修复能力的差异相关，并可能影响个体对吸烟相关癌症的易感性。我们调查了韩国人群中DNA修复基因XPA的两种多态性与肺癌风险之间的关联。在265例肺癌患者和185例年龄和性别频率匹配的健康对照中对两种XPA多态性（A23G和G709A）进行分型。在病例组和对照组中均未检测到XPA G709A多态性。当将AA和AG基因型合并作为参照时，XPA 23 GG基因型与肺癌风险显著降低相关[比值比（OR），0.56；95%置信区间（CI），0.35 - 0.90]。XPA 23 GG基因型的风险降低在男性（OR，0.51；95% CI，0.30 - 0.86）、较年轻个体（OR，0.39；95% CI，0.19 - 0.80）和当前吸烟者（OR，0.46；95% CI，0.25 - 0.83）中显著。这些结果表明XPA A23G多态性与肺癌的遗传易感性有关。
