Lou Yuqing, Li Rong, Zhang Yanwei, Zhong Runbo, Pei Jun, Xiong Liwen, Zhang Xueyan, Han Baohui
Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiaotong University, 241 West Huaihai Road, Shanghai, 200030, People's Republic of China.
Tumour Biol. 2014 Jul;35(7):6607-17. doi: 10.1007/s13277-014-1824-1. Epub 2014 Apr 3.
No clear consensus has been reached on the XPA gene rs1800975 polymorphism and lung cancer risk. We performed a meta-analysis in an effort to systematically explore the possible association. We conducted a computer retrieval of PubMed, Embase, Wanfang, China National Knowledge Infrastructure Platform, and VIP databases prior to November 2013. References of retrieved articles were also screened. The fixed- and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. According to the inclusion criteria, 10 articles (11 studies) were finally included. In overall, statistical association could be found between rs1800975 polymorphism and lung cancer in recessive genetic model [AA vs. (AG + GG): P = 0.02, OR = 1.16, 95% CI 1.02-1.31, P heterogeneity = 0.14, fixed-effects model]. In the East Asians, significant association was found in allele comparison model (A vs. G: P = 0.03, OR = 1.13, 95% CI 1.01-1.26, P heterogeneity = 0.39, fixed-effects model), in recessive genetic model [AA vs. (AG + GG): P = 0.005, OR = 1.30, 95% CI 1.08-1.56, P heterogeneity = 0.58, fixed-effects model] and in the homozygote comparison (AA vs. GG: P = 0.02, OR = 1.30, 95% CI 1.04-1.63, P heterogeneity = 0.39, fixed-effects model). No evidence suggested that rs1800975 polymorphism might associate with lung cancer in other ethnicities. Stratification analysis performed by histologic types indicated that AA genotype might represent a risk factor for squamous cell carcinoma [AA vs. (AG + GG): P = 0.01, OR = 1.42, 95% CI 1.08-1.86, P heterogeneity = 0.27, fixed-effects model; AA vs. GG: P = 0.03, OR = 1.43, 95% CI 1.04-1.96, P heterogeneity = 0.21, fixed-effects model]. No association was observed in adenocarcinoma subgroup. Our study suggested that XPA rs1800975 polymorphism might associate with lung cancer risk in overall and in East Asians. This polymorphism might also associate with squamous cell carcinoma.
关于XPA基因rs1800975多态性与肺癌风险，尚未达成明确的共识。我们进行了一项荟萃分析，以系统地探究可能的关联。在2013年11月之前，我们对PubMed、Embase、万方、中国知网和维普数据库进行了计算机检索。还筛选了检索文章的参考文献。对于二分结果，应用固定效应模型和随机效应模型来合并各个研究的结果。根据纳入标准，最终纳入10篇文章（11项研究）。总体而言，在隐性遗传模型中可发现rs1800975多态性与肺癌之间存在统计学关联[AA与(AG + GG)比较：P = 0.02，OR = 1.16，95%CI 1.02 - 1.31，P异质性 = 0.14，固定效应模型]。在东亚人群中，在等位基因比较模型中发现显著关联（A与G比较：P = 0.03，OR = 1.13，95%CI
