[2%环孢素A滴眼液治疗特应性和春季角结膜炎]

[Cyclosporin A 2% eyedrops in therapy of atopic and vernal keratoconjunctivitis].

作者信息

Tomida I, Schlote T, Bräuning J, Heide P E, Zierhut M

机构信息

Universitäts-Augenklinik, Abteilung I, Universität Tübingen, Germany.

出版信息

Ophthalmologe. 2002 Oct;99(10):761-7. doi: 10.1007/s00347-001-0600-y.

DOI:10.1007/s00347-001-0600-y

PMID:12376851

Abstract

BACKGROUND

The efficacy of Cyclosporin A 2%eyedrops (CsA2%) as an additive treatment of atopic (AKC) and vernal keratoconjunctivitis (VKC) was evaluated.

PATIENTS AND METHODS

The symptoms and findings of 26 patients with AKC and 12 patients with VKC with no improvement under conventional therapy, were additionally treated with CsA2% eyedrops and compared over a minimum follow-up period of 3 months to more than 24 months.

RESULTS

The therapy with CsA2% eyedrops was well tolerated and evaluated as effective by the patients. Subtarsal papillae were reduced in 69.2% of the AKC group and in 66.6% of the VKC patients. Trantas dots were reduced or disappeared in about 50% of the AKC group and in the VKC group they had disappeared in more than 50%. Subjective symptoms (e.g. itching) had also been reduced or eliminated.

CONCLUSION

CsA2% eyedrops are effective in the treatment of AKC and VKC, reducing objective and subjective signs as well as the need of adding topical steroids in affected patients.

摘要