Schröder A, Delling G, Kaiser E A
Abteilung Osteopathologie/Zentrum für Biomechanik, Pathologisches Institut, Universitätskrankenhaus Hamburg-Eppendorf, Hamburg, Germany.
Pathologe. 2002 Sep;23(5):361-6. doi: 10.1007/s00292-002-0557-x. Epub 2002 Aug 14.
Expression analysis of the protein tyrosine kinases, focal adhesion kinase (FAK) and proline-rich tyrosine kinase2 (Pyk2) in high grade osteosarcomas.
Expression of the kinases was evaluated qualitatively by immunohistochemical staining and quantitatively by real-time PCR.
Osteoblastic cells of high grade osteosarcomas show a distinct FAK expression but an overexpression at the transcriptional level could not be detected. The Pyk2-mRNA expression was decreased in osteosarcomas.
An altered relationship of FAK and Pyk2 was observed for different tumors and could also be important for osteosarcoma development.
对高级别骨肉瘤中蛋白酪氨酸激酶、粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（Pyk2）进行表达分析。
通过免疫组织化学染色对激酶表达进行定性评估，并通过实时PCR进行定量评估。
高级别骨肉瘤的成骨细胞显示出明显的FAK表达，但未检测到转录水平的过表达。骨肉瘤中Pyk2 - mRNA表达降低。
不同肿瘤中观察到FAK和Pyk2的关系改变，这对骨肉瘤的发展也可能很重要。
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