Voltz R
Institut für Klinische Neuroimmunologie, Klinikum Grosshadern, München, Germany.
Nervenarzt. 2002 Oct;73(10):909-29. doi: 10.1007/s00115-002-1407-z.
All complications of tumor disease that do not result from the tumor itself, its metastases, or vascular, infectious, metabolic, or therapy-related causes are referred to as paraneoplastic neurologic syndromes. This earlier represented an excluding diagnosis and the association was established only statistically, but since the first description of the anti-Hu antibody in 1985, we know that around 2/3 of patients with paraneoplastic disorders display highly specific antibody reactions in the serum. These reactions not only prove a paraneoplastic etiology in almost 100% of cases, but, due to their highly specific associations with certain tumor types, also aid tumor detection in patients whose tumor types are not known.
所有并非由肿瘤本身、其转移灶、血管、感染、代谢或治疗相关原因引起的肿瘤疾病并发症，均被称为副肿瘤性神经综合征。这在早期是一种排除性诊断，且这种关联仅通过统计学确立，但自1985年首次描述抗Hu抗体以来，我们知道约2/3的副肿瘤性疾病患者血清中会出现高度特异性的抗体反应。这些反应不仅在几乎100%的病例中证实了副肿瘤性病因，而且由于它们与某些肿瘤类型的高度特异性关联，还有助于在肿瘤类型不明的患者中检测肿瘤。
