Belousov P V, Shebzukhov Iu V, Nedospasov S A, Kuprash D V
Mol Gen Mikrobiol Virusol. 2007(2):6-13.
Paraneoplastic neurological syndromes (PNS) are autoimmune neurodegenerative diseases that develop as a result of the cross-reactivity of the tumor-specific immune effectors with neurons of central and peripheral nervous systems. So-called onconeural antibodies, which are detected in sera of PNS patients, are not only crucial diagnostic markers of PNS and associated tumors, but also have a considerable potential in the serological diagnosis of cancer as a whole. In this review we discuss the role of onconeural antibodies in serological diagnosis of PNS and associated tumors as well as their potential in diagnosis and prognostication of a broad spectrum of malignant tumors.
副肿瘤性神经系统综合征（PNS）是一种自身免疫性神经退行性疾病，由肿瘤特异性免疫效应器与中枢和外周神经系统神经元的交叉反应引起。在PNS患者血清中检测到的所谓肿瘤神经抗体，不仅是PNS和相关肿瘤的关键诊断标志物，而且在整个癌症的血清学诊断中也具有相当大的潜力。在这篇综述中，我们讨论了肿瘤神经抗体在PNS和相关肿瘤血清学诊断中的作用，以及它们在广泛恶性肿瘤诊断和预后中的潜力。
