Schönfeldt-Lecuona C, Walter H, Connemann B J, Kassubek J, Spitzer M, Herwig U
Abteilung Psychiatrie III, Universitätsklinik Ulm, Germany.
Fortschr Neurol Psychiatr. 2002 Oct;70(10):520-30. doi: 10.1055/s-2002-34670.
The antidepressant effect of repetitive transcranial magnetic stimulation (rTMS) has been studied intensively over the last years. Numerous studies worldwide yielded variable results ranging from ineffectivity to an efficacy rate of more than 50 % for the reduction of depressive symptoms. A comparison of the effectiveness of TMS across studies is difficult due to the variety of chosen stimulation parameters, different inclusion criteria, and different designs. The discrepancies in results could be partially in account to these factors. From a pathophysiological point of view, there are no empirically justified parameters published carrying out an antidepressant TMS. Further studies are required to find optimal stimulation parameters using complementary methods like functional imaging techniques or regarding other factors that could interfere with its efficacy. An overview of studies published in the last ten years, a critical analysis of stimulation procedures and protocols, and possible future perspectives of this method are reviewed in this article.
在过去几年中，人们对重复经颅磁刺激（rTMS）的抗抑郁作用进行了深入研究。世界各地的大量研究得出了各不相同的结果，从无效到减轻抑郁症状的有效率超过50%不等。由于所选择的刺激参数、不同的纳入标准和不同的设计各不相同，因此很难在各项研究之间比较经颅磁刺激的有效性。结果的差异可能部分归因于这些因素。从病理生理学角度来看，目前尚无关于实施抗抑郁经颅磁刺激的经实证验证的参数。需要进一步开展研究，以使用功能成像技术等补充方法或考虑其他可能干扰其疗效的因素来找到最佳刺激参数。本文综述了过去十年发表的研究概况、对刺激程序和方案的批判性分析以及该方法可能的未来前景。
