Sharpe Amanda L, Samson Herman H
Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA.
Alcohol. 2002 Aug;28(1):1-7. doi: 10.1016/s0741-8329(02)00238-0.
Nicotine and alcohol are two of the most used drugs in the United States. However, it is not clear whether the co-use of these drugs is due to pharmacological or environmental reasons, or perhaps related to both. Although results from previous studies in animal models seem to indicate that nicotine has an effect on ethanol consumption, little has been done to determine how nicotine affects appetitive and consummatory phases of ethanol self-administration. In this study, we examined the effect of repeated treatment with nicotine (0, 0.35, and 0.7 mg/kg, s.c.), given 30 min before a daily operant session, on appetitive and consummatory phases of Long-Evans rats self-administering 10% (vol./vol.) ethanol in a sipper-tube model. Ethanol intake (consummatory phase) decreased at both doses of nicotine tested, and lever pressing (appetitive phase) decreased after injection of the high dose of nicotine. These results support the suggestion that nicotine affects ethanol self-administration. However, in this model, the findings demonstrate a reduction in drinking, rather than the enhancement that has been shown in findings obtained from other studies.
尼古丁和酒精是美国使用最为广泛的两种毒品。然而，尚不清楚同时使用这些毒品是由于药理原因还是环境原因，亦或是两者皆有。尽管先前在动物模型中的研究结果似乎表明尼古丁对乙醇消费有影响，但对于尼古丁如何影响乙醇自我给药的食欲和满足阶段，却鲜有研究。在本研究中，我们检测了在每日操作性实验前30分钟皮下注射尼古丁（0、0.35和0.7毫克/千克）对Long-Evans大鼠在吸管模型中自我给药10%（体积/体积）乙醇的食欲和满足阶段的影响。在测试的两种尼古丁剂量下，乙醇摄入量（满足阶段）均下降，而在注射高剂量尼古丁后，杠杆按压（食欲阶段）减少。这些结果支持了尼古丁影响乙醇自我给药的观点。然而，在这个模型中，研究结果表明饮酒量减少，而非其他研究结果中显示的增加。
