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母乳及断奶对人类小肠上皮生长的影响。

Effect of breast milk and weaning on epithelial growth of the small intestine in humans.

作者信息

Cummins A G, Thompson F M

机构信息

Bazil Hetzel Research Institute and the Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

出版信息

Gut. 2002 Nov;51(5):748-54. doi: 10.1136/gut.51.5.748.

DOI:10.1136/gut.51.5.748
PMID:12377819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1773445/
Abstract

Breast feeding and weaning are important physiologically significant luminal events that influence the growth of the small intestine in humans. A variety of factors including genetic preprogramming, systemic and local hormones, and permissive factors contribute and modulate intestinal growth. Here, we offer a view that integrates some of these factors, especially those relating to breast feeding and weaning.

摘要

母乳喂养和断奶是重要的具有生理意义的管腔事件,会影响人类小肠的生长。多种因素,包括基因预编程、全身和局部激素以及许可因子,都会对肠道生长产生影响并进行调节。在此,我们提出一种整合了其中一些因素的观点,特别是那些与母乳喂养和断奶相关的因素。

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本文引用的文献

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INTESTINAL INVERTASE: PRECOCIOUS DEVELOPMENT OF ACTIVITY AFTER INJECTION OF HYDROCORTISONE.肠蔗糖酶:注射氢化可的松后活性的早熟发育。
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Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha.缺乏表皮生长因子(EGF)、双调蛋白和转化生长因子-α(TGF-α)的三基因敲除小鼠出现生长迟缓、十二指肠病变和回肠结构异常。
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Functional characterization of the keratinocyte growth factor system in human fetal gastrointestinal tract.人胎儿胃肠道中角质形成细胞生长因子系统的功能特性
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Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.人及啮齿动物中胰高血糖素样肽-2受体表达的肠内分泌定位。
Gastroenterology. 2000 Sep;119(3):744-55. doi: 10.1053/gast.2000.16489.
7
Cytokine gene expression during postnatal small intestinal development: regulation by glucocorticoids.出生后小肠发育过程中的细胞因子基因表达:糖皮质激素的调节作用
Gut. 2000 Aug;47(2):192-8. doi: 10.1136/gut.47.2.192.
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Glucocorticoids have pleiotropic effects on small intestinal crypt cells.糖皮质激素对小肠隐窝细胞具有多效性作用。
Am J Physiol. 1999 Nov;277(5):G1027-40. doi: 10.1152/ajpgi.1999.277.5.G1027.
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Difluoromethylornithine inhibits crypt fission.二氟甲基鸟氨酸抑制隐窝裂变。
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Activation of the gut-associated lymphoid tissue with expression of interleukin-2 receptors that peaks during weaning in the rat.肠道相关淋巴组织的激活以及白细胞介素-2受体的表达在大鼠断奶期间达到峰值。
J Pediatr Gastroenterol Nutr. 1999 Nov;29(5):556-62. doi: 10.1097/00005176-199911000-00016.