Singh Dave, Sutton Chris, Woodcock Ashley
Lung Function Unit, North West Lung Research Center, South Manchester University Hospital Trust, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
Chest. 2002 Oct;122(4):1299-301. doi: 10.1378/chest.122.4.1299.
It is recommended that the PPD Mantoux tuberculin test be read at 48 or 72 h. We have compared the measurements at these time points.
A 10-tuberculin unit (TU) PPD Mantoux test was administered to 116 healthy subjects (76.7% with bacillus Calmette-Guérin scars).
One hundred sixteen healthy adult volunteers were recruited (health service employees, 29 volunteers; general public, 87 volunteers).
The measurements made at 72 h were significantly higher than those made at 48 h (median, 9.4 vs 4.95 mm, respectively; p = 0.017). In those subjects with induration at either or both time points (n = 69), the readings taken at 72 h were on average 1.7 mm (95% confidence interval, 0.4 to 3.0 mm) larger than those at 48 h. Using an induration of > 15 mm diameter to define a positive result, there were more positive test results at 72 h (36) compared to 48 h (28), with the results from 10 subjects (8.5%) changing because of the time of measurement.
This study demonstrates that, in adults, the size of the 10-TU Mantoux reaction is significantly larger at 72 h compared to the reaction at 48 h. In clinical practice, tuberculin tests should be read at 72 h as negative tests at 48 h may be false results.
建议在48或72小时读取结核菌素纯蛋白衍生物（PPD）曼托试验结果。我们比较了这两个时间点的测量值。
对116名健康受试者（76.7%有卡介苗接种疤痕）进行了10结核菌素单位（TU）的PPD曼托试验。
招募了116名健康成年志愿者（卫生服务人员29名，普通公众87名）。
72小时时的测量值显著高于48小时时的测量值（中位数分别为9.4 mm和4.95 mm；p = 0.017）。在两个时间点之一或两个时间点均出现硬结的受试者（n = 69）中，72小时时的读数平均比48小时时大1.7 mm（95%置信区间为0.4至3.0 mm）。使用硬结直径> 15 mm来定义阳性结果，72小时时的阳性试验结果（36例）比48小时时（28例）更多，10名受试者（8.5%）的结果因测量时间而改变。
本研究表明，在成年人中，10 - TU曼托反应的大小在72小时时显著大于48小时时。在临床实践中，结核菌素试验应在72小时读取，因为48小时时的阴性试验结果可能是假阴性。
