Velasco F, Velasco M, Jimenez F, Velasco A L, Marquez I
Unit for Stereotactic and Functional Neurosurgery, General Hospital, Mexico City, Mexico.
Stereotact Funct Neurosurg. 2001;77(1-4):228-32. doi: 10.1159/000064611.
Electrical stimulation of the centromedian thalamic nucleus (ESCM) has been used in cases of difficult to control seizures with multifocal onset in frontal and temporal lobes, as well as in cases of seizures with no evidence of focal onset, such as Lennox-Gastaut syndrome. The stimulation program consists of 1 min stimulation on one side, 4 min interval OFF stimulation and 1 min stimulation on the other side, alternating from one side to the other for 24 h, at 60-130 Hz, 2.5-5.0 V, 0.21-0.45 ms. 49 cases have been treated and followed for periods of 6 months to 15 years. Results indicate that ESCM is highly efficient to control generalized tonic clonic seizures (GTC), atypical absences (AA) and tonic seizures (TS) and less efficient to control complex partial seizures (CxP).
电刺激中央中丘脑核（ESCM）已用于治疗额叶和颞叶多灶性发作且难以控制的癫痫病例，以及无局灶性发作证据的癫痫病例，如伦诺克斯 - 加斯东综合征。刺激程序包括一侧刺激1分钟，间隔4分钟无刺激，另一侧刺激1分钟，两侧交替进行24小时，频率为60 - 130Hz，电压为2.5 - 5.0V，脉宽为0.21 - 0.45ms。已治疗49例，并随访了6个月至15年。结果表明，ESCM对控制全身强直阵挛性发作（GTC）、非典型失神发作（AA）和强直性发作（TS）非常有效，而对控制复杂部分性发作（CxP）效果较差。
