Torrão Andréa S, Britto Luiz R G
Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
An Acad Bras Cienc. 2002 Sep;74(3):453-61. doi: 10.1590/s0001-37652002000300008.
Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be unrelated to their role in cholinergic neurotransmission in the vertebrate brain. Both temporal expression data and in vitro and in vivo studies with nicotinic agonists and antagonists have provided direct support for a role of nicotinic receptors in neural developmental processes such as neurite outgrowth and differentiation. A similar picture has emerged for other neurotransmitter and receptor systems as well, which generates a new view of neural processes during both development and mature life.
在过去十年中，几种神经递质系统已被证明与发育过程有关。在这篇综述中，我们讨论了这样的证据：烟碱型乙酰胆碱受体在发育过程中可能具有额外的功能，这一功能可能与其在脊椎动物大脑胆碱能神经传递中的作用无关。烟碱型激动剂和拮抗剂的时间表达数据以及体外和体内研究都直接支持了烟碱型受体在神经发育过程（如神经突生长和分化）中的作用。其他神经递质和受体系统也呈现出类似的情况，这为发育和成熟生命过程中的神经活动带来了新的视角。
