McCluggage W Glenn, O'Rourke Declan, McElhenney Clodagh, Crooks Michael
Department of Pathology, Royal Group of Hospitals Trust, and the Department of Pathology, Belfast City Hospital, Ireland.
Hum Pathol. 2002 Sep;33(9):944-6. doi: 10.1053/hupa.2002.127437.
This report describes an unusual epithelial proliferation occurring in pelvic cystic endosalpingiosis. A cyst mass lined by a layer of ciliated epithelial cells involved the posterior surface of the cervix and vagina. The epithelial proliferation within the wall resembled a mullerian papilloma with fibrous and fibrovascular cores lined by bland cuboidal epithelial cells. Other areas had a microglandular growth pattern resembling cervical microglandular hyperplasia, and focally there was a solid growth pattern. Foci of typical endosalpingiosis involved the surface of both ovaries and pelvic soft tissues. The cystic lesion recurred after partial cystectomy and drainage and was followed up radiologically and with periodic fine-needle aspiration. Part of the wall of the cyst removed 11 years after the original surgery showed an identical epithelial proliferation. MIB1 staining showed a proliferation index of less than 5%, contrasting with the higher proliferation index of a typical serous borderline tumor. The differential diagnosis is discussed. As far as we are aware, this is the first report of such a benign epithelial proliferation involving cystic endosalpingiosis.
本报告描述了盆腔囊性输卵管内膜异位症中发生的一种不寻常的上皮增生。一个由一层纤毛上皮细胞衬里的囊肿块累及宫颈和阴道后表面。壁内的上皮增生类似于有纤维和纤维血管核心、由温和的立方上皮细胞衬里的苗勒管乳头状瘤。其他区域有类似于宫颈微小腺体增生的微小腺体生长模式，局部有实性生长模式。典型输卵管内膜异位症病灶累及双侧卵巢表面和盆腔软组织。囊肿性病变在部分囊肿切除及引流后复发，并进行了放射学随访及定期细针穿刺。初次手术后11年切除的囊肿部分壁显示相同的上皮增生。MIB1染色显示增殖指数小于5%，与典型浆液性交界性肿瘤较高的增殖指数形成对比。讨论了鉴别诊断。据我们所知，这是关于这种累及囊性输卵管内膜异位症的良性上皮增生的首例报告。
