骨科手术后的急性血栓性血小板减少性紫癜
Acute thrombotic thrombocytopenic purpura following orthopedic surgery.
作者信息
Kathula Satheesh K, Kamana Mallika, Naqvi Tahir, Gupta Sharda, Chang Jae C
机构信息
Department of Medicine, Wright State University, Dayton, Ohio.
出版信息
J Clin Apher. 2002;17(3):133-4. doi: 10.1002/jca.10027.
Release of unusually large von Willibrand factor (UL vWF) multimers and a deficiency of vWF metalloprotease may result in thrombotic thrombocytopenic purpura (TTP), a life threatening disease. Surgery has been associated with TTP, probably by releasing massive amounts of UL vWF. An association between TTP and orthopedic surgery has never been reported in the literature. We report a case of TTP following a total knee replacement surgery in which prior use of ticlopidine might have played a role.
超大血管性血友病因子（UL vWF）多聚体的释放以及vWF金属蛋白酶的缺乏可能导致血栓性血小板减少性紫癜（TTP），这是一种危及生命的疾病。手术与TTP有关，可能是通过释放大量的UL vWF。TTP与骨科手术之间的关联在文献中从未有过报道。我们报告了一例全膝关节置换术后发生TTP的病例，其中先前使用噻氯匹定可能起到了一定作用。
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