[对51名70岁以上患者的意义未明单克隆丙种球蛋白病的随访]

[Follow-up of monoclonal gammopathy of undetermined significance in a population of 51 patients older than 70 years ].

作者信息

Decaux O, Cazalets-Lacoste C, Cador-Rousseau B, Laurat E, Sebillot M, Bracq J, Jego P, Leblay R, Grosbois B

机构信息

Département de médecine de l'adulte, hôpital Sud, 16, boulevard de Bulgarie, 35056 Rennes, France.

出版信息

Rev Med Interne. 2002 Sep;23(9):751-8. doi: 10.1016/s0248-8663(02)00671-9.

DOI:10.1016/s0248-8663(02)00671-9

PMID:12378828

Abstract

UNLABELLED

Monoclonal gammopathy of undetermined significance (MGUS) are very frequent in the elderly. Its incidence is about 3% after 70 years. We have performed a retrospective study of patients aged of more than 70 years who were examined until 1995 for a MGUS.

METHODS

The study included 51 patients: 24 men and 27 women. Information about evolution was obtained by medical file or by asking medical practitioner. We know the evolution of all patients until January 1st 2000. The median follow-up is 5.8 years (70 months).

RESULTS

The MGUS remained stable for 34 patients (67%) with a median follow-up of 83 months (12 to 180 months). Nine patients (17%) developed malignant transformation of MGUS (6 multiple myeloma, 2 Waldenström macroglobulinemia, 1 malignant lymphoma). Eight (15%) developed a cancer. Twelve died without evidence of multiple myeloma or related disorder. The actuarial probability of malignant transformation at 5 years was 12%.

CONCLUSION

The risk of malignant transformation of MGUS doesn't decrease in the elderly. A regular and prolonged follow-up is necessary.

摘要

未分类

意义未明的单克隆丙种球蛋白病（MGUS）在老年人中非常常见。70岁以后其发病率约为3%。我们对1995年以前接受检查的70岁以上MGUS患者进行了一项回顾性研究。

方法

该研究纳入了51例患者，其中男性24例，女性27例。通过病历或询问医生获取病情进展信息。我们了解了所有患者截至2000年1月1日的病情进展。中位随访时间为5.8年（70个月）。

结果

34例患者（67%）的MGUS病情保持稳定，中位随访时间为83个月（12至180个月）。9例患者（17%）发生了MGUS的恶性转化（6例多发性骨髓瘤，2例华氏巨球蛋白血症，1例恶性淋巴瘤）。8例（15%）发生了癌症。12例患者死亡，未发现多发性骨髓瘤或相关疾病的证据。5年时恶性转化的精算概率为12%。