酰胺化胃泌素和甘氨酸延伸型胃泌素对经肠外和经口喂养大鼠的细胞增殖和隐窝裂变的影响。
Effects of amidated gastrin and glycine-extended gastrin on cell proliferation and crypt fission in parenterally and orally fed rats.
作者信息
FitzGerald Anthony J, Ghatei Mohammad A, Mandir Nikki, Bloom Steven R, Iversen Leslie, Goodlad Robert A
机构信息
Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
出版信息
Digestion. 2002;66(1):58-66. doi: 10.1159/000064423.
BACKGROUND/AIMS: It has been suggested that processing variants of gastrin, such as glycine-extended gastrin (G17-Gly), are enterotrophic to the colon.
METHODS
Cell proliferation and crypt branching were studied in total parenteral nutrition (TPN) and orally fed rats after infusion of G17-Gly or gastrin-17.
RESULTS
Gastrin produced an increase in the weight of the stomach and small intestine and a marked proliferative action on the proximal small intestine, which diminished distally. No proliferative effects of gastrin were seen in the colon. G17-Gly was associated with a small, but significant, increase in colonic weight but had little effect on cell proliferation, except in the gastric fundus. In the distal colon, G17-Gly was associated with a significant decrease in proliferation. Neither agent affected crypt branching in the small intestine or colon, but both proliferation and branching were significantly decreased by TPN.
CONCLUSION
Gastrin was trophic to the stomach and the proximal small intestine but not the colon. G17-Gly had only modest proliferative actions on the intestinal epithelium in this study.
背景/目的：有研究表明，胃泌素的加工变体，如甘氨酸延伸型胃泌素（G17-Gly），对结肠具有肠营养作用。
方法
在全胃肠外营养（TPN）大鼠和经口喂养大鼠中，输注G17-Gly或胃泌素-17后，研究细胞增殖和隐窝分支情况。
结果
胃泌素使胃和小肠重量增加，并对近端小肠产生显著的增殖作用，这种作用在远端逐渐减弱。在结肠中未观察到胃泌素的增殖作用。G17-Gly与结肠重量的小幅但显著增加有关，但对细胞增殖影响较小，胃底除外。在远端结肠，G17-Gly与增殖的显著降低有关。两种药物均未影响小肠或结肠的隐窝分支，但TPN显著降低了增殖和分支。
结论
胃泌素对胃和近端小肠有营养作用，但对结肠没有。在本研究中，G17-Gly对肠上皮细胞仅有适度的增殖作用。
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