Schneider Rayfel, Passo Murray H
Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Room 8253, Toronto, ON M5G 1X8, Canada.
Rheum Dis Clin North Am. 2002 Aug;28(3):503-30. doi: 10.1016/s0889-857x(02)00016-9.
Progress in achieving international consensus concerning the classification of juvenile idiopathic arthritis has been made, although further refinement and validation of these criteria is needed. It is hoped that this will facilitate more effective international collaboration in the study of these diseases, because much remains to be learned about genetic susceptibility, causation, pathogenesis, and treatment. Attention to the unique aspects of chronic arthritis in children such as impaired growth and macrophage activation syndrome may help to reduce disease-related morbidity and mortality. New biologic agents have substantially enhanced the treatment of JRA. The identification of reliable predictors of disease course and outcome is important in the rational and timely application of new therapies.
在青少年特发性关节炎的分类方面已达成国际共识，不过这些标准仍需进一步完善和验证。希望这将促进在这些疾病研究方面更有效的国际合作，因为在遗传易感性、病因、发病机制及治疗方面仍有许多有待了解之处。关注儿童慢性关节炎的独特方面，如生长发育受损和巨噬细胞活化综合征，可能有助于降低疾病相关的发病率和死亡率。新型生物制剂显著改善了幼年类风湿关节炎的治疗。识别疾病进程和结局的可靠预测指标对于合理及时应用新疗法至关重要。
