[锝-99m] - 甲氧基异丁基异腈在局部晚期乳腺癌中的摄取和洗脱与肿瘤血流相关。
[Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow.
作者信息
Mankoff David A, Dunnwald Lisa K, Gralow Julie R, Ellis Georgiana K, Schubert Erin K, Charlop Aaron W, Tseng Jeffrey, Rinn Kristine J, Livingston Robert B
机构信息
Division of Nuclear Medicine, University of Washington, Seattle, WA, USA.
出版信息
Nucl Med Biol. 2002 Oct;29(7):719-27. doi: 10.1016/s0969-8051(02)00333-5.
OBJECTIVES
To determine the influence of breast tumor blood flow on MIBI kinetics, we compared MIBI uptake and washout to [O-15]-water PET estimates of blood flow in patients with locally advanced breast cancer.
METHODS
Prior to therapy, 37 patients underwent MIBI and [O-15]-water PET imaging; 22/37 also had MIBI washout analysis. Twenty-five patients underwent serial imaging over the course of chemotherapy.
RESULTS
MIBI uptake and blood flow had a significant positive correlation pre-therapy. The change in MIBI uptake over the course of therapy also correlated with the change in blood flow. The half-time of MIBI washout inversely correlated with blood flow, indicating faster MIBI washout with higher blood flow.
CONCLUSIONS
Blood flow strongly influences early MIBI uptake and can be a factor affecting the rate of MIBI washout in breast tumors. We present a model of MIBI kinetics in tumors which forms a hypothesis for further mechanistic studies of MIBI uptake and washout in breast cancer.
目的
为了确定乳腺肿瘤血流对MIBI动力学的影响，我们比较了局部晚期乳腺癌患者的MIBI摄取和洗脱情况与用[O-15] -水PET估算的血流情况。
方法
在治疗前，37例患者接受了MIBI和[O-15] -水PET成像；37例中的22例还进行了MIBI洗脱分析。25例患者在化疗过程中接受了系列成像检查。
结果
治疗前MIBI摄取与血流呈显著正相关。治疗过程中MIBI摄取的变化也与血流的变化相关。MIBI洗脱的半衰期与血流呈负相关，表明血流越高，MIBI洗脱越快。
结论
血流强烈影响早期MIBI摄取，并且可能是影响乳腺肿瘤中MIBI洗脱速率的一个因素。我们提出了一个肿瘤中MIBI动力学模型，该模型为进一步对乳腺癌中MIBI摄取和洗脱进行机制研究形成了一个假设。
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