Margulis M S, Rosenthal R L, Daugulis E C, Sondore A A, Krivulis D B, Andreiman L A, Kvizinskaja E A
Crit Care Med. 1975 Nov-Dec;3(6):226-30. doi: 10.1097/00003246-197511000-00004.
Of 45 patients observed in the ICU with severe acute hepatic insufficiency, 15 patients were in hepatic coma. All patients received combined treatment consisting of standard conservative methods (drug therapy) and surgical methods for temporary support of liver function (hemodialysis, exchange blood transfusion, pig liver perfusion). Intensive therapy which began during the early phase of hepatic coma enabled us to bring six patients out of the coma, four of whom completely recovered. These studies showed that of the diseases causing hepatic coma, the worst results were obtained with viral hepatitis. This may be explained both by the extensive liver damage and marked metabolic disturbances, which led to failure of other vital organs and systems. At present, the combined therapy contributes to a greater percentage of recovery of patients with hepatic failure and coma.
在重症监护病房观察的45例严重急性肝功能不全患者中，15例处于肝昏迷状态。所有患者均接受了由标准保守方法（药物治疗）和临时支持肝功能的手术方法（血液透析、换血输血、猪肝灌注）组成的联合治疗。在肝昏迷早期开始的强化治疗使6例患者苏醒，其中4例完全康复。这些研究表明，在导致肝昏迷的疾病中，病毒性肝炎的治疗效果最差。这可能是由于广泛的肝损伤和明显的代谢紊乱，导致其他重要器官和系统功能衰竭。目前，联合治疗有助于提高肝衰竭和昏迷患者的康复率。
