Sakamoto Noriho, Mukae Hiroshi, Kakugawa Tomoyuki, Nagata Towako, Kaida Hideyuki, Ishii Hiroshi, Abe Kou, Kadota Jun-ichi, Matsukura Shigeru, Kohno Shigeru
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Nihon Kokyuki Gakkai Zasshi. 2002 Jul;40(7):564-8.
We studied cell findings in the bronchoalveolar lavage fluid (BALF) of 13 patients with nonspecific interstitial pneumonia (NSIP) and 20 with ordinary interstitial pneumonia (UIP). NSIP and UIP were difficult to distinguish by high-resolution CT. Surgical lung biopsies were performed in all patients. We divided the patients with NSIP and UIP into 4 groups, a group of idiopathic NSIP (idiopathic NSIP), a group of NSIP patients associated with collagen vascular disease (CVD NSIP), a group of idiopathic UIP patients (idiopathic UIP) and a group of UIP patients associated with collagen vascular disease (CVD UIP). We then examined the differences in BALF cell findings between these groups. The percentage of lymphocytes in BALF was higher in idiopathic NSIP and CVD NSIP than in the healthy control. The percentage of alveolar macrophages was lower and the percentage of lymphocytes was higher in CVD NSIP than in idiopathic UIP. The CD4/CD8 ratio in BALF of idiopathic NSIP was lower than with idiopathic UIP. It is important that NSIP be distinguished from UIP clinically, and our results suggest that BALF cell findings may be useful for making this distinction.
我们研究了13例非特异性间质性肺炎（NSIP）患者和20例普通间质性肺炎（UIP）患者支气管肺泡灌洗液（BALF）中的细胞情况。NSIP和UIP通过高分辨率CT难以区分。所有患者均进行了外科肺活检。我们将NSIP和UIP患者分为4组，一组特发性NSIP（特发性NSIP），一组与胶原血管病相关的NSIP患者（CVD NSIP），一组特发性UIP患者（特发性UIP）和一组与胶原血管病相关的UIP患者（CVD UIP）。然后我们检查了这些组之间BALF细胞情况的差异。特发性NSIP和CVD NSIP中BALF中淋巴细胞的百分比高于健康对照组。CVD NSIP中肺泡巨噬细胞的百分比低于特发性UIP，淋巴细胞的百分比高于特发性UIP。特发性NSIP的BALF中CD4/CD8比值低于特发性UIP。临床上区分NSIP和UIP很重要，我们的结果表明BALF细胞情况可能有助于进行这种区分。
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