Yokoiyama S, Ando T, Hayano K, Fujiwara K
Jikken Dobutsu. 1975 Jul;24(3):103-10.
Latent infection with Corynebacterium kutscheri in mice and its provocation by cortisone were studied with a rifampicin-resistant strain of the organism. Mice having been infected perorally began to excrete the organisms in feces within 6 hours, and most of them were found to be carrying the organisms in the intestine, especially in the cecum even 90 days after infection. In such state of latency, however, no organisms were detected in other main organs, and neither visible lesions nor serum agglutinin was detectable. The latent infection with excretion of the organisms in feces after peroral infection was shown to become overt and fatal by cortisone treatment made even 90 days after infection. In infected mice excreting no organisms in feces and having bites on their skin, the wounds became severe ulcers after cortisone treatment resulting in septicemia.
利用一株对利福平耐药的库氏棒状杆菌菌株，对小鼠的库氏棒状杆菌潜伏感染及其由可的松引发的情况进行了研究。经口感染的小鼠在6小时内开始在粪便中排出该菌，并且发现它们中的大多数在感染后90天仍在肠道中携带该菌，尤其是在盲肠中。然而，在这种潜伏状态下，在其他主要器官中未检测到该菌，也未检测到明显病变或血清凝集素。经口感染后粪便中排出该菌的潜伏感染，在感染后90天进行的可的松治疗可使其变为显性且致命。在粪便中不排出该菌且皮肤有咬伤的感染小鼠中，可的松治疗后伤口会变成严重溃疡，导致败血症。
