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小鼠nm23-M2、nm23-M3和nm23-M4基因的特征:与其人类直系同源基因的比较。

Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs.

作者信息

Massé K, Dabernat S, Bourbon P-M, Larou M, Amrein L, Barraud P, Perel Y, Camara M, Landry M, Lacombe M-L, Daniel J-Y

机构信息

Biologie de la Différenciation et du Développement, Université Victor Segalen-Bordeaux2, 146 rue Léo Saignat, France.

出版信息

Gene. 2002 Aug 21;296(1-2):87-97. doi: 10.1016/s0378-1119(02)00836-3.

Abstract

The nm23 gene family is thought to be involved in physiopathological processes such as growth, differentiation and cancer promotion, progression or metastasis. We report here the mouse nm23-M3 and nm23-M4 complementary DNA sequences and the genomic cloning, characterization and tissue expression pattern of the nm23-M2, nm23-M3 and nm23-M4 genes, in comparison with their human and rat orthologs and with the human nm23-H1 and mouse nm23-M1 genes. The organization and structure of the members of this gene family are remarkably similar in human and rodents. Accordingly, the striking similarities between the human and mouse nm23 genes enable the use of mouse transgenic and knock-out models for studying the role of nucleoside diphosphate kinase isoforms in human physiopathology.

摘要

nm23基因家族被认为参与了诸如生长、分化以及癌症的发生、发展或转移等生理病理过程。我们在此报告小鼠nm23-M3和nm23-M4互补DNA序列,以及nm23-M2、nm23-M3和nm23-M4基因的基因组克隆、特征分析和组织表达模式,并将其与人类和大鼠的直系同源基因以及人类nm23-H1和小鼠nm23-M1基因进行比较。该基因家族成员的组织和结构在人类和啮齿动物中非常相似。因此,人类和小鼠nm23基因之间的显著相似性使得利用小鼠转基因和基因敲除模型来研究核苷二磷酸激酶同工型在人类生理病理中的作用成为可能。

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