Solorzano Carmen C, Middleton Lavinia P, Hunt Kelly K, Mirza Nadeem, Meric Funda, Kuerer Henry M, Ross Merrick I, Ames Frederick C, Feig Barry W, Pollock Raphael E, Singletary S Eva, Babiera Gildy
Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Am J Surg. 2002 Oct;184(4):364-8. doi: 10.1016/s0002-9610(02)00941-8.
Intracystic papillary carcinoma (IPC) of the breast is a rare form of noninvasive breast cancer. An appreciation of associated pathology with IPC may be critical in surgical decision-making.
The medical records of all patients with IPC treated between 1985 and 2001 were retrospectively reviewed. Three patient groups were identified according to the pathologic features of the primary tumor: IPC alone, IPC with associated ductal carcinoma in situ (DCIS), and IPC with associated invasion with or without DCIS. Types of treatment and outcomes were compared between groups.
Forty patients were treated for IPC during the study period. Fourteen had pure IPC, 13 had IPC with DCIS, and 13 had IPC with invasion. The incidence of recurrence and the likelihood of dying of IPC did not differ between the three groups regardless of the type of surgery (mastectomy or segmental mastectomy) performed and whether radiation therapy was administered. The disease-specific survival rate was 100%.
When IPC is identified, it is frequently associated with DCIS and or invasion. Standard therapy should be based on associated pathology. The role of radiation therapy in pure IPC remains to be determined.
乳腺囊内乳头状癌(IPC)是一种罕见的非侵袭性乳腺癌。了解IPC相关的病理学特征对于手术决策可能至关重要。
回顾性分析1985年至2001年间接受治疗的所有IPC患者的病历。根据原发肿瘤的病理特征将患者分为三组:单纯IPC、伴有导管原位癌(DCIS)的IPC以及伴有浸润(无论有无DCIS)的IPC。比较三组之间的治疗类型和结果。
在研究期间,40例患者接受了IPC治疗。14例为单纯IPC,13例为伴有DCIS的IPC,13例为伴有浸润的IPC。无论进行何种手术(乳房切除术或乳房区段切除术)以及是否进行放射治疗,三组之间IPC的复发率和死亡率均无差异。疾病特异性生存率为100%。
当确诊为IPC时,其常与DCIS和/或浸润相关。标准治疗应基于相关病理学特征。放射治疗在单纯IPC中的作用尚待确定。