Glassheim Elyssa, Zhou Jain, Fine Stephanie, Falk Nadja K, Torrez Mary
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Department of Surgery, Division of Surgical Oncology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Case Rep Pathol. 2025 Aug 28;2025:6518104. doi: 10.1155/crip/6518104. eCollection 2025.
Encapsulated papillary carcinoma (EPC) is an invasive carcinoma which shows papillary architecture within a thickened fibrous capsule. Multiple studies have shown that this tumor follows an indolent course with excellent prognosis, and as such, it is recommended that it be staged as in situ lesions. It is an uncommonly encountered tumor most often diagnosed in postmenopausal females. As breast cancer in males is overall rare, available data on diagnosis, management, and outcomes of EPC in males is limited. Typically, cases of EPC that present with advanced stage and/or lymph node metastases show an associated invasive process. We present a case of pure EPC in a male patient with associated skin ulceration and positive lymph nodes, leading to a final stage of ypT4bN1a. The present report underscores the indolent nature of EPC, even when diagnosed at an advanced stage.
囊内乳头状癌(EPC)是一种浸润性癌,在增厚的纤维性囊内呈乳头状结构。多项研究表明,这种肿瘤病程惰性,预后良好,因此建议将其分期为原位病变。它是一种罕见的肿瘤,最常诊断于绝经后女性。由于男性乳腺癌总体罕见,关于男性EPC的诊断、治疗和预后的可用数据有限。通常,表现为晚期和/或淋巴结转移的EPC病例显示有相关的浸润过程。我们报告一例男性纯EPC患者,伴有皮肤溃疡和淋巴结阳性,最终分期为ypT4bN1a。本报告强调了EPC的惰性本质,即使在晚期诊断时也是如此。