Redrobe John P, Dumont Yvan, Quirion Rémi
Douglas Hospital Research Centre, Department of Psychiatry, Institute of Neuroscience, Mental Health and Addiction, McGill University, 6875 LaSalle Blvd., Montreal, Quebec, Canada H4H 1R3.
Life Sci. 2002 Nov 8;71(25):2921-37. doi: 10.1016/s0024-3205(02)02159-8.
Neuropeptide Y (NPY) is widely distributed throughout the central nervous system (CNS) and is one of the most conserved peptides in evolution, suggesting an important role in the regulation of basic physiological functions. In addition, both pre-clinical and clinical evidence have suggested that NPY, together with its receptors, may have a direct implication in several psychiatric disorders, including depression and related illnesses. NPY-like immunoreactivity and NPY receptors are expressed throughout the brain, with varying concentrations being found throughout the limbic system. Such brain structures have been repeatedly implicated in the modulation of emotional processing, as well as in the pathogenesis of depressive disorders. This review will concentrate on the distribution of NPY, its receptors, and the putative role played by this peptide in depressive illness based on both pre-clinical and clinical evidence.
神经肽Y（NPY）广泛分布于中枢神经系统（CNS），是进化过程中最保守的肽类之一，这表明它在基本生理功能调节中发挥着重要作用。此外，临床前和临床证据均表明，NPY及其受体可能与包括抑郁症及相关疾病在内的多种精神障碍直接相关。NPY样免疫反应性和NPY受体在整个大脑中均有表达，在边缘系统中浓度各异。此类脑结构反复被认为与情绪加工的调节以及抑郁症的发病机制有关。本综述将基于临床前和临床证据，聚焦于NPY及其受体的分布，以及该肽在抑郁症中可能发挥的作用。
