Nakagawara M, Sato Y
Department of Psychiatry, Yokosuka Kyosai Hospital, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Jun;14(3):117-27.
Neuropeptide Y is a 36-amino acid peptide that is widely distributed in the brain. Recently, three neuropeptide Y receptor subtypes were discovered with the aid of peptidergic agonist analogs of neuropeptide Y. Many researchers reported that neuropeptide Y might be involved in locomotor activity, eating behavior, stress responses, memory processing, circadian rhythms, blood pressure and neuroendocrine functions. It was also reported to interact with sigma receptor and corticotropin-releasing factor. Clinical evidence suggests that neuropeptide Y might be related to depression, schizophrenia, anorexia nervosa and Alzheimer's disease. In this review, central distribution and receptor subtypes of neuropeptide Y, its physiological action and its levels in cerebrospinal fluid and plasma in psychiatric and neurological illnesses are described.
神经肽Y是一种由36个氨基酸组成的肽，广泛分布于大脑中。最近，借助神经肽Y的肽能激动剂类似物发现了三种神经肽Y受体亚型。许多研究人员报告称，神经肽Y可能参与运动活动、进食行为、应激反应、记忆处理、昼夜节律、血压和神经内分泌功能。也有报道称它与σ受体和促肾上腺皮质激素释放因子相互作用。临床证据表明，神经肽Y可能与抑郁症、精神分裂症、神经性厌食症和阿尔茨海默病有关。在这篇综述中，描述了神经肽Y的中枢分布和受体亚型、其生理作用以及在精神和神经疾病患者脑脊液和血浆中的水平。
