莫西沙星对临床分离株的活性与环丙沙星的活性比较。

Moxifloxacin activity against clinical isolates compared with the activity of ciprofloxacin.

作者信息

Aktaş Zerrin, Gönüllü Nevriye, Salcioğlu Melek, Bal Ciğdem, Anğ Ozdem

机构信息

Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, University of Istanbul, 34390 Capa, Istanbul, Turkey.

出版信息

Int J Antimicrob Agents. 2002 Sep;20(3):196-200. doi: 10.1016/s0924-8579(02)00174-7.

DOI:10.1016/s0924-8579(02)00174-7

PMID:12385698

Abstract

The activity of moxifloxacin, a new 8-methoxyquinolone, was compared in vitro with the activity of ciprofloxacin against clinical strains isolated from various sites of infection. The mode MIC values of moxifloxacin were superior to those of ciprofloxacin against Streptococcus pneumoniae, methicillin-susceptible and -resistant Staphylococcus aureus, Enterococcus spp., Escherichia coli and Acinetobacter spp., while ciprofloxacin was more active against Klebsiella pneumoniae and Pseudomonas spp. Both antibiotics had similar activity against Haemophilus influenzae, Moraxella catarrhalis and Enterobacter spp.

摘要

将新型8-甲氧基喹诺酮类药物莫西沙星的活性与环丙沙星对从各种感染部位分离出的临床菌株的活性进行了体外比较。莫西沙星的MIC值模式在针对肺炎链球菌、甲氧西林敏感和耐药金黄色葡萄球菌、肠球菌属、大肠杆菌和不动杆菌属方面优于环丙沙星，而环丙沙星对肺炎克雷伯菌和假单胞菌属更具活性。两种抗生素对流感嗜血杆菌、卡他莫拉菌和肠杆菌属具有相似的活性。