Serrano Deborah Regina, Zanotti-Magalhaes Eliana Maria, Magalhaes Luiz Augusto, Ferreira de Carvalho José
Departamento de Parasitologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil.
Mem Inst Oswaldo Cruz. 2002 Sep;97(6):881-5.
Since the internal defense system of mollusks consists of cellular and humoral mechanisms, we examined the role of hydrocortisone in mollusks defense cells and the influence of this steroid on the development of Schistosoma mansoni in its intermediary host. Hydrocortisone had an immunosuppressive action in Biomphalaria glabrata, as reflected in the reduced number of defense cells and the altered cell physiology. Histopathological analysis showed that hydrocortisone facilitated the intramolluscan development of S. mansoni, by reducing the extent of the inflammatory response, seen as a greater number of viable sporocysts with no surrounding hemocytes.
由于软体动物的内防御系统由细胞和体液机制组成，我们研究了氢化可的松在软体动物防御细胞中的作用以及这种类固醇对曼氏血吸虫在其中间宿主中发育的影响。氢化可的松在光滑双脐螺中具有免疫抑制作用，这表现为防御细胞数量减少和细胞生理改变。组织病理学分析表明，氢化可的松通过减少炎症反应的程度，促进了曼氏血吸虫在软体动物体内的发育，表现为有更多没有周围血细胞的活孢子蚴。
