Landau Irène M E, Steen Björn, Seregard Stefan
St. Eriks Eye Hospital, Karolinska Institute, Stockholm, Sweden.
Acta Ophthalmol Scand. 2002 Oct;80(5):531-6. doi: 10.1034/j.1600-0420.2002.800513.x.
To assess the efficacy of photodynamic therapy (PDT) as a new treatment for circumscribed choroidal haemangioma (CCH).
Eight patients with CCH were treated with PDT using a protocol similar to that used in the standard treatment of neovascular age-related macular degeneration.
Visual acuity improved in six of eight eyes, remained unchanged in one eye and deteriorated in one eye after 3-15 months (median 7 months) follow-up. Pre-treatment metamorphopsia disappeared in all but two cases. The thickness of the CCH measured with standardized echography showed marked regression within 1 month after PDT. In six eyes there was no remaining protrusion after PDT and one lesion was barely detectable. One patient experienced a transient choroidal effusion and perifoveal haemorrhage.
Photodynamic therapy is a promising new treatment for CCH as it restores visual function in most cases without causing apparent ocular or systemic side-effects.
评估光动力疗法(PDT)作为局限性脉络膜血管瘤(CCH)新治疗方法的疗效。
8例CCH患者接受了PDT治疗,采用的方案类似于用于新生血管性年龄相关性黄斑变性标准治疗的方案。
经过3 - 15个月(中位时间7个月)的随访,8只眼中有6只眼视力提高,1只眼视力不变,1只眼视力下降。除2例患者外,治疗前的视物变形均消失。采用标准化超声检查测量的CCH厚度在PDT后1个月内显示出明显消退。6只眼在PDT后没有残留的突出,1个病灶几乎无法检测到。1例患者出现短暂性脉络膜积液和黄斑周围出血。
光动力疗法是一种有前景的CCH新治疗方法,因为它在大多数情况下能恢复视觉功能,且不会引起明显的眼部或全身副作用。