Nandi Dipankar, Aziz Tipu Z, Giladi Nir, Winter Jonathan, Stein John F
University Laboratory of Physiology, Oxford University, UK.
Brain. 2002 Nov;125(Pt 11):2418-30. doi: 10.1093/brain/awf259.
Recent studies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem has extensive connections with several motor centres in the CNS. This structure has also been implicated in the akinesia seen in patients with Parkinson's disease. Here we demonstrate that microinjection of gamma-aminobutyric acid (GABA) receptor A antagonist substance, bicuculline, into the PPN of non-human primates (n = 2) rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) results in significant improvement of akinesia. The effect of bicuculline microinjection in the PPN matches that of oral administration of L-dopa. This finding opens up new possibilities in the management of akinesia, the most intractable symptom of advanced Parkinson's disease.
近期主要针对动物的研究表明，中脑上部的脚桥核（PPN）与中枢神经系统中的多个运动中枢有着广泛的联系。这种结构也与帕金森病患者出现的运动不能有关。在此我们证明，向非人类灵长类动物（n = 2）的PPN中微量注射γ-氨基丁酸（GABA）A受体拮抗剂荷包牡丹碱，会导致用1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱发的帕金森病模型出现运动不能显著改善。在PPN中微量注射荷包牡丹碱的效果与口服左旋多巴的效果相当。这一发现为治疗晚期帕金森病最棘手的症状——运动不能开辟了新的可能性。
