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Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board.针对帕金森病中的脚桥核：是时候重新审视了。
Mov Disord. 2018 Dec;33(12):1871-1875. doi: 10.1002/mds.27540. Epub 2018 Nov 6.
2
Improvement of hand dexterity induced by stimulation of the peduncolopontine nucleus in a patient with advanced Parkinson's disease and previous long-lasting bilateral subthalamic DBS.刺激脑桥被盖脚核可改善晚期帕金森病且曾行长期双侧丘脑底核脑深部电刺激患者的手部灵活性。
Acta Neurochir (Wien). 2011 Aug;153(8):1587-90. doi: 10.1007/s00701-011-1051-0. Epub 2011 Jun 3.
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Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus: effects on gait in Parkinson's disease.脑深部电刺激苍白球和丘脑底核对帕金森病步态的影响。
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Structural brain changes following subthalamic nucleus deep brain stimulation in Parkinson's disease.帕金森病患者丘脑底核深部脑刺激后的脑结构变化
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Deep brain stimulation for parkinsonian gait disorders.用于帕金森步态障碍的深部脑刺激
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J Parkinsons Dis. 2023;13(4):563-573. doi: 10.3233/JPD-225031.
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Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections.谷氨酸能的脚桥被盖核神经元通过不同的轴突投射来控制觉醒和运动。
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NPJ Parkinsons Dis. 2022 Jan 11;8(1):8. doi: 10.1038/s41531-021-00276-6.
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Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.探讨帕金森病步态障碍的研究重点。
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Deep brain stimulation of the Cuneiform nucleus for levodopa-resistant freezing of gait in Parkinson's disease: study protocol for a prospective, pilot trial.帕金森病中对楔状核进行深部脑刺激治疗左旋多巴抵抗性步态冻结：一项前瞻性试点试验的研究方案
Pilot Feasibility Stud. 2021 Jun 2;7(1):117. doi: 10.1186/s40814-021-00855-7.
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Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071.TAK-071 通过 M1 PAM 减少 PD 跌倒大鼠模型中的跌倒次数。
Psychopharmacology (Berl). 2021 Jul;238(7):1953-1964. doi: 10.1007/s00213-021-05822-x. Epub 2021 Mar 18.
10
Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation.剖析脑干运动回路：楔形核刺激的汇聚证据
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本文引用的文献

1
Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP-induced primate model of Parkinson disease.MPTP 诱导的帕金森病灵长类模型中尾状网状结构和脑桥被盖核的棘波放电特征。
Neurobiol Dis. 2019 Aug;128:40-48. doi: 10.1016/j.nbd.2018.08.002. Epub 2018 Aug 4.
2
Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease: MRI-Based Anatomoclinical Correlations and Optimal Target.帕金森病的脑桥被盖核区深部脑刺激：基于 MRI 的解剖-临床相关性和最佳靶点。
Neurosurgery. 2019 Feb 1;84(2):506-518. doi: 10.1093/neuros/nyy151.
3
Midbrain circuits that set locomotor speed and gait selection.中脑回路设定运动速度和步态选择。
Nature. 2018 Jan 25;553(7689):455-460. doi: 10.1038/nature25448. Epub 2018 Jan 17.
4
Nonhuman Primate Optogenetics: Recent Advances and Future Directions.非人灵长类动物光遗传学：最新进展与未来方向。
J Neurosci. 2017 Nov 8;37(45):10894-10903. doi: 10.1523/JNEUROSCI.1839-17.2017.
5
Locomotor speed control circuits in the caudal brainstem.尾部脑干中的运动速度控制回路。
Nature. 2017 Nov 16;551(7680):373-377. doi: 10.1038/nature24064. Epub 2017 Oct 23.
6
Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons.被盖脚桥核谷氨酸能神经元控制黑质多巴胺能神经元的棘波模式。
Elife. 2017 Oct 5;6:e30352. doi: 10.7554/eLife.30352.
7
Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: A clinical review.苍白球腹侧部脑深部电刺激治疗帕金森病的临床研究进展
Mov Disord. 2018 Jan;33(1):10-20. doi: 10.1002/mds.27098. Epub 2017 Sep 28.
8
Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function.重新思考脑桥被盖核：从细胞组织到功能。
Neuron. 2017 Apr 5;94(1):7-18. doi: 10.1016/j.neuron.2017.02.027.
9
Deep Brain Stimulation of Pedunculopontine Nucleus for Postural Instability and Gait Disorder After Parkinson Disease: A Meta-Analysis of Individual Patient Data.帕金森病后姿势不稳和步态障碍的脑桥脚核深部脑刺激：个体患者数据的荟萃分析
World Neurosurg. 2017 Jun;102:72-78. doi: 10.1016/j.wneu.2017.02.110. Epub 2017 Mar 6.
10
Thalamic cholinergic innervation makes a specific bottom-up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses.丘脑胆碱能神经支配对信号检测有特定的自下而上的贡献：来自患有明确胆碱能缺失的帕金森病患者的证据。
Neuroimage. 2017 Apr 1;149:295-304. doi: 10.1016/j.neuroimage.2017.02.006. Epub 2017 Feb 5.

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board.

作者信息

Albin Roger L, Surmeier D James, Tubert Cecilia, Sarter Martin, Müller Martijn L T M, Bohnen Nicolaas I, Dauer William T

机构信息

Neurology Service & Geriatrics Research, Education, and Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.

Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.

出版信息

Mov Disord. 2018 Dec;33(12):1871-1875. doi: 10.1002/mds.27540. Epub 2018 Nov 6.

DOI:10.1002/mds.27540
PMID:30398673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6448144/
Abstract
摘要