Okumura M, Ohta M, Tomiyama N, Minami M, Hirabayashi H, Matsuda H
Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Kyobu Geka. 2002 Oct;55(11):916-20.
WHO classification of thymic epithelial tumors have been shown to reflect their oncological behaviors, and type A, AB and B1 tumors have better prognosis than type B2 and B3 tumors, suggesting the significance of this classification in the clinical practice of thymomas. Type B tumors are more invasive than type A and AB tumors. Type B1 and B2 tumors are frequently associated with myasthenia gravis while type A and AB tumors are not. The findings of computed tomography (CT) imaging revealed that type A and AB tumors tend to be round and have the smooth surface while type B1, B2 and B3 tumors are often flat and have irregular surface. Type AB, B1 and B2 tumors possess a significant number of CD4+CD8+ double positive T cells in the tumor. These observations are supposed to be useful for preoperative evaluation of WHO classification of thymomas, and to help the clinicians decide application of preoperative therapy and the method of surgical resection including endoscopic surgery.
世界卫生组织（WHO）对胸腺上皮肿瘤的分类已被证明能反映其肿瘤学行为，A 型、AB 型和 B1 型肿瘤的预后优于 B2 型和 B3 型肿瘤，这表明该分类在胸腺瘤临床实践中的重要性。B 型肿瘤比 A 型和 AB 型肿瘤更具侵袭性。B1 型和 B2 型肿瘤常与重症肌无力相关，而 A 型和 AB 型肿瘤则不然。计算机断层扫描（CT）成像结果显示，A 型和 AB 型肿瘤往往呈圆形且表面光滑，而 B1 型、B2 型和 B3 型肿瘤通常扁平且表面不规则。AB 型、B1 型和 B2 型肿瘤在肿瘤中含有大量 CD4 + CD8 + 双阳性 T 细胞。这些观察结果应该有助于胸腺瘤 WHO 分类的术前评估，并帮助临床医生决定术前治疗的应用以及包括内镜手术在内的手术切除方法。
