用于双功能抗氧化剂/铁螯合剂增溶的前药和共价连接策略。
Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators.
作者信息
Bebbington David, Dawson Claire E, Gaur Suneel, Spencer John
机构信息
Department of Chemistry, Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, UK.
出版信息
Bioorg Med Chem Lett. 2002 Nov 18;12(22):3297-300. doi: 10.1016/s0960-894x(02)00698-4.
Abstract
Water soluble prodrugs of hybrid free radical scavenger/iron chelating molecules, based on 3,5-disubstituted-4-hydroxyphenyl derivatives and 3-hydroxy-2-methyl-4(1H)-pyridinone (deferiprone), have been prepared. Related hybrid molecules containing a covalent poly(ethylene)glycol or an amine linker were also synthesized.
摘要
基于3,5 - 二取代 - 4 - 羟基苯基衍生物和3 - 羟基 - 2 - 甲基 - 4(1H) - 吡啶酮（去铁酮），制备了具有自由基清除剂/铁螯合分子特性的水溶性前药。还合成了含有共价聚乙二醇或胺连接体的相关杂化分子。
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