Heenen M, Lambert J C, Achten G, Galand P
J Natl Cancer Inst. 1975 Apr;54(4):825-7.
A double labeling method with two levels of tritiated thymidine was used to study 6 patients with seborrheic keratosis, 1 with a fibroepithelial tumor of Pinkus, and 1 with basal cell nevus syndrome manifesting three pits on the palm of the hand. The two latter types of lesions, known to be able to evolve into basal cell carcinoma, had an increased S-phase duration (18 hr for the germ cells of the palmar pits) as compared with normal epidermis (10 hr). This situation was similar to that observed in basal cell carcinoma, However, the S phase was not lengthened in seborrheic keratosis (9.2 plus or minus 1.6), a benign tumor in which malignant transformation is extremely rare. S phase was also of normal duration in the benign eosinophilic septa of the tumor of Pinkus.
采用含有两个氚标记胸腺嘧啶核苷水平的双重标记法，对6例脂溢性角化病患者、1例平卡斯纤维上皮瘤患者和1例手掌有三个凹陷的基底细胞痣综合征患者进行了研究。已知后两种类型的病变能够演变成基底细胞癌，与正常表皮（10小时）相比，它们的S期持续时间增加（手掌凹陷处生殖细胞为18小时）。这种情况与在基底细胞癌中观察到的情况相似。然而，脂溢性角化病（9.2±1.6）的S期没有延长，脂溢性角化病是一种恶性转化极为罕见的良性肿瘤。平卡斯瘤的良性嗜酸性间隔中的S期持续时间也正常。
