Chubakov A R, Nikonov A A, Gromova E A
Neirofiziologiia. 1975;7(6):581-8.
Background spike activity and morphological characteristics of the visual cortex neurons 1-2 day old rats were investigated under conditions of long-term (up to 34 days) tissue cultures. Three types of unit activity were found: single (regular) spikes, bursts and group discharges. Background activity is shown to depend on the cultivation period. Regular firing of neurons for the first 7-15 cultivation days is changed later by bursts or group activity. These changes in neuronal activity coincide in time with the process of morphological maturation of synaptic connections. Strychnine caused a distinct increase in the mean frequency of background activity accompanied by separate series of group discharges. On the basis of the data obtained the problem on the genesis of the spontaneous activity in cortical neurons is discussed.
在长期（长达34天）组织培养条件下，对1 - 2日龄大鼠视觉皮层神经元的背景放电活动和形态特征进行了研究。发现了三种类型的单位活动：单个（规则）放电、爆发式放电和群体放电。结果表明，背景活动取决于培养时间。在培养的前7 - 15天，神经元的规则放电随后会被爆发式放电或群体活动所取代。神经元活动的这些变化在时间上与突触连接的形态成熟过程相吻合。士的宁导致背景活动的平均频率显著增加，并伴有一系列单独的群体放电。基于所获得的数据，讨论了皮层神经元自发活动的起源问题。
